{"id":1750,"date":"2019-04-19T18:46:06","date_gmt":"2019-04-19T22:46:06","guid":{"rendered":"https:\/\/myendoconsult.com\/learn\/?p=1750"},"modified":"2023-03-16T06:28:44","modified_gmt":"2023-03-16T11:28:44","slug":"anti-thyroid-drugs","status":"publish","type":"post","link":"https:\/\/myendoconsult.com\/learn\/anti-thyroid-drugs\/","title":{"rendered":"Anti-Thyroid Drugs (Mechanism of Action)"},"content":{"rendered":"<p>Thionamides are a class of drugs that are used to treat hyperthyroidism. The mechanism of action of thionamides is not fully understood, but it is thought to involve the inhibition of TPO-mediated coupling and the suppression of T cell-mediated immunity.<\/p>\n<p>Thionamides also decreases the activity of type 1 deiodinase, which is responsible for the activation of T4 (that is its conversion to active thyroid hormone, T3). The result is a decrease in T3 levels and an increase in T4 levels. The net effect is a decrease in <a href=\"https:\/\/myendoconsult.com\/learn\/thyroid-hormone-synthesis\/\">thyroid hormone<\/a> production and an improvement in symptoms.<\/p>\n<p><a href=\"https:\/\/myendoconsult.com\/learn\/wp-content\/uploads\/2019\/04\/antithyroid-drugs.png\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"57a9a6c\" data-elementor-lightbox-title=\"antithyroid drugs\" data-elementor-lightbox-description=\"Mechanism of action of anti-thyroid drugs\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/myendoconsult.com\/learn\/wp-content\/uploads\/2019\/04\/antithyroid-drugs-722x1024.png\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" srcset=\"https:\/\/myendoconsult.com\/learn\/wp-content\/uploads\/2019\/04\/antithyroid-drugs-722x1024.png 722w, https:\/\/myendoconsult.com\/learn\/wp-content\/uploads\/2019\/04\/antithyroid-drugs-211x300.png 211w, https:\/\/myendoconsult.com\/learn\/wp-content\/uploads\/2019\/04\/antithyroid-drugs-768x1090.png 768w, https:\/\/myendoconsult.com\/learn\/wp-content\/uploads\/2019\/04\/antithyroid-drugs.png 1748w\" alt=\"Mechanism of action of anti-thyroid drugs\" width=\"640\" height=\"908\" aria-describedby=\"gallery-1-1752\" \/><\/a>Mechanism of action of anti-thyroid drugs<\/p>\n<p>Liu L, Lu H, Liu Y, Liu C, Xun C. Predicting relapse of <a href=\"https:\/\/myendoconsult.com\/learn\/graves-disease-and-pregnancy\/\">Graves&#8217; disease<\/a> following treatment with antithyroid drugs.<a href=\"https:\/\/doi.org\/10.3892\/etm.2016.3058\" target=\"_blank\" rel=\"noopener\"> Exp Ther Med. 2016 Apr;11(4):1453-1458.<\/a><\/p>\n<p>Cooper DS. Antithyroid drugs.<a href=\"https:\/\/doi.org\/10.1056\/nejmra042972\" target=\"_blank\" rel=\"noopener\"> N Engl J Med. 2005 Mar 3;352(9):905-17.\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thionamides are a class of drugs that are used to treat hyperthyroidism. The mechanism of action of thionamides is not fully understood, but it is thought to involve the inhibition of TPO-mediated coupling and the suppression of T cell-mediated immunity. Thionamides also decreases the activity of type 1 deiodinase, which is responsible for the activation [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1441,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[45],"tags":[],"class_list":["post-1750","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mechanisms","post-wrapper","thrv_wrapper"],"_links":{"self":[{"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/posts\/1750","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/comments?post=1750"}],"version-history":[{"count":27,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/posts\/1750\/revisions"}],"predecessor-version":[{"id":4416107,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/posts\/1750\/revisions\/4416107"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/media\/1441"}],"wp:attachment":[{"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/media?parent=1750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/categories?post=1750"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/tags?post=1750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}