{"id":1771,"date":"2019-04-20T00:06:45","date_gmt":"2019-04-20T04:06:45","guid":{"rendered":"https:\/\/myendoconsult.com\/learn\/?p=1771"},"modified":"2023-03-16T06:27:54","modified_gmt":"2023-03-16T11:27:54","slug":"cushing-disease-medications-mechanism-of-action","status":"publish","type":"post","link":"https:\/\/myendoconsult.com\/learn\/cushing-disease-medications-mechanism-of-action\/","title":{"rendered":"Cushing disease medications (Mechanism of Action)"},"content":{"rendered":"

The mechanism of action of Somatostatin receptor ligands, Dopamine Agonists, Steroidogenesis inhibitors, Glucocorticoid receptor antagonists, and Retinoic acid modulators will be reviewed.<\/p>\n

Somatostatin analogs<\/h2>\n

Somatostatin analogs\u00a0are drugs that mimic the action of somatostatin, a hormone that inhibits the release of other hormones, including cortisol. The most commonly used somatostatin analog is\u00a0pasireotide\u00a0(Signifor), which is effective in lowering cortisol levels and improving symptoms.<\/p>\n

Retinoic acid (RA)<\/h2>\n

Retinoic acid (RA)\u00a0is a medical treatment for Cushing\u2019s syndrome. RA works by inhibiting the production of\u00a0COUP-TF1, a protein that is essential for cortisol synthesis. As a result, RA can help to reduce the levels of cortisol in the body and improve the symptoms of Cushing\u2019s syndrome<\/a>. While RA is not a cure for Cushing\u2019s syndrome, it can help to manage the condition and improve the quality of life for patients.<\/p>\n

Steroidogenesis inhibitors<\/h2>\n

Steroidogenesis inhibitors\u00a0are a class of drugs that are used to treat Cushing\u2019s syndrome by reducing the production of cortisol. The most common agents in this class are ketoconazole, metyrapone, and mitotane. These drugs work by inhibiting the enzymes involved in cortisol synthesis in the adrenal gland. While they are effective at reducing cortisol levels, they can also cause significant side effects, such as gastrointestinal distress, adrenal insufficiency, and hepatotoxicity.<\/p>\n

Mifepristone<\/h2>\n

Mifepristone (RU-486)\u00a0is a synthetic steroid with anti-progestational and anti-glucocorticoid activity. It is a competitive inhibitor of progesterone and cortisol at the\u00a0glucocorticoid receptor, and thus prevents the maturation of the corpus luteum, suppresses ovulation, and antagonizes the action of endogenous cortisol.<\/p>\n

\"\"<\/a>Mechanism of Action of medications in Cushing’s syndrome<\/p>\n

References<\/h2>\n