{"id":3572804,"date":"2022-05-12T00:04:00","date_gmt":"2022-05-12T04:04:00","guid":{"rendered":"https:\/\/myendoconsult.com\/learn\/?p=3572804"},"modified":"2024-12-26T21:45:00","modified_gmt":"2024-12-27T03:45:00","slug":"acth-conversion-calculator-pmol-l-to-pg-ml","status":"publish","type":"post","link":"https:\/\/myendoconsult.com\/learn\/acth-conversion-calculator-pmol-l-to-pg-ml\/","title":{"rendered":"ACTH Conversion calculator pmol\/L to pg\/mL"},"content":{"rendered":"\n<!DOCTYPE html>\n<html>\n<head>\n  <meta charset=\"UTF-8\">\n  <title>ACTH pg\/mL \u2194 pmol\/L Convertor<\/title>\n  <style>\n    \/* =====================\n       BASIC RESET & PAGE STYLES\n       ===================== *\/\n    * {\n      box-sizing: border-box;\n      margin: 0;\n      padding: 0;\n    }\n    body {\n      font-family: Arial, sans-serif;\n      background-color: #f7f7f7;\n      padding: 20px;\n    }\n\n    \/* =====================\n       CONVERTER CONTAINER\n       ===================== *\/\n    .converter-container {\n      width: 100%;\n      max-width: 600px; \/* limit width on larger screens *\/\n      margin: 0 auto;   \/* center horizontally *\/\n      background: #fff;\n      padding: 20px;\n      border-radius: 8px;\n      border: 1px solid #ccc;\n    }\n    h1, h2 {\n      text-align: center;\n      color: #333;\n      margin-bottom: 10px;\n    }\n    p {\n      margin-bottom: 15px;\n      line-height: 1.4;\n      color: #555;\n    }\n\n    \/* =====================\n       LABELS & TEXTAREAS\n       ===================== *\/\n    label {\n      font-weight: bold;\n      display: block;\n      margin-top: 10px;\n      color: #333;\n    }\n    .textarea-group {\n      display: flex;\n      flex-wrap: wrap; \/* ensures columns wrap on small screens *\/\n      gap: 20px;\n      margin-bottom: 15px;\n    }\n    .textarea-group > div {\n      flex: 1 1 250px; \/* grows\/shrinks, min 250px *\/\n      min-width: 0;    \/* helps prevent overflow *\/\n    }\n    textarea {\n      width: 100%;\n      height: 130px;\n      padding: 8px;\n      margin-top: 5px;\n      resize: vertical;\n      border: 1px solid #ccc;\n      border-radius: 4px;\n    }\n\n    @media (max-width: 600px) {\n      .textarea-group {\n        flex-direction: column; \/* stack the two boxes vertically on small screens *\/\n      }\n    }\n\n    \/* =====================\n       INPUT FOR DECIMALS\n       ===================== *\/\n    #decimalsInput {\n      width: 100%;\n      margin: 5px 0 15px 0;\n      padding: 8px;\n      border: 1px solid #ccc;\n      border-radius: 4px;\n      box-sizing: border-box;\n    }\n\n    \/* =====================\n       BUTTONS\n       ===================== *\/\n    .buttons {\n      text-align: center;\n      margin-top: 20px;\n    }\n    button {\n      padding: 10px 15px;\n      margin: 5px;\n      cursor: pointer;\n      border: none;\n      border-radius: 4px;\n      font-size: 16px;\n    }\n    #calculateBtn {\n      background-color: #007bff;\n      color: #fff;\n    }\n    #resetBtn {\n      background-color: #6c757d;\n      color: #fff;\n    }\n\n    \/* =====================\n       FOOTER NOTE\n       ===================== *\/\n    .note {\n      font-size: 14px;\n      color: #777;\n      margin-top: 15px;\n      text-align: center;\n    }\n  <\/style>\n<\/head>\n<body data-rsssl=1>\n\n<!-- =====================\n     MAIN CONVERTER WRAPPER\n     ===================== -->\n<div class=\"converter-container\">\n  <h1>Corticotropin (ACTH) Convertor<\/h1>\n  <h2>pg\/mL \u2194 pmol\/L<\/h2>\n\n  <p>\n    Enter values in <strong>pg\/mL<\/strong> <em>or<\/em> in <strong>pmol\/L<\/strong>, \n    then click <strong>Calculate<\/strong>.<br>\n    You may convert multiple values at once by separating them with commas, \n    spaces, tabs, or new lines.\n  <\/p>\n\n  <!-- ========== TEXTAREAS ========== -->\n  <div class=\"textarea-group\">\n    <div>\n      <label for=\"pgmlInput\">Corticotropin (ACTH) pg\/mL<\/label>\n      <textarea \n        id=\"pgmlInput\" \n        placeholder=\"e.g., 10, 20, 30\"><\/textarea>\n    <\/div>\n    <div>\n      <label for=\"pmolInput\">Corticotropin (ACTH) pmol\/L<\/label>\n      <textarea \n        id=\"pmolInput\" \n        placeholder=\"e.g., 2.20, 4.40, 8.80\"><\/textarea>\n    <\/div>\n  <\/div>\n\n  <!-- ========== DECIMAL INPUT ========== -->\n  <label for=\"decimalsInput\">Decimals (e.g., 2)<\/label>\n  <input \n    type=\"number\" \n    id=\"decimalsInput\" \n    min=\"0\" \n    step=\"1\" \n    placeholder=\"2\"\n  \/>\n\n  <!-- ========== BUTTONS ========== -->\n  <div class=\"buttons\">\n    <button id=\"calculateBtn\">Calculate<\/button>\n    <button id=\"resetBtn\">Reset<\/button>\n  <\/div>\n\n  <!-- ========== FOOTER \/ NOTES ========== -->\n  <div class=\"note\">\n    <p><strong>Conversion Factors:<\/strong><\/p>\n    <p>1 pg\/mL = 0.22 pmol\/L &nbsp; | &nbsp; 1 pmol\/L = 4.545 pg\/mL<\/p>\n    <p>Always refer to clinical guidelines, patient factors, and professional judgment.<\/p>\n  <\/div>\n<\/div>\n\n<script>\ndocument.addEventListener(\"DOMContentLoaded\", function() {\n  \/\/ Conversion factors\n  const FACTOR_PG_TO_PMOL = 0.22;    \/\/ 1 pg\/mL = 0.22 pmol\/L\n  const FACTOR_PMOL_TO_PG = 1 \/ 0.22; \/\/ 1 pmol\/L = 4.545... pg\/mL\n\n  \/\/ Get references to DOM elements\n  const pgmlInput    = document.getElementById(\"pgmlInput\");\n  const pmolInput    = document.getElementById(\"pmolInput\");\n  const decimalsInput = document.getElementById(\"decimalsInput\");\n  const calculateBtn  = document.getElementById(\"calculateBtn\");\n  const resetBtn      = document.getElementById(\"resetBtn\");\n\n  \/\/ Event listeners\n  calculateBtn.addEventListener(\"click\", doConversion);\n  resetBtn.addEventListener(\"click\", resetFields);\n\n  \/**\n   * doConversion:\n   * Determines which box (pg\/mL or pmol\/L) is filled,\n   * splits multiple values, converts, and displays in the other box.\n   *\/\n  function doConversion() {\n    const pgmlStr = pgmlInput.value.trim();\n    const pmolStr = pmolInput.value.trim();\n\n    \/\/ Determine desired decimals (default to 2 if empty or invalid)\n    let decimals = parseInt(decimalsInput.value, 10);\n    if (isNaN(decimals) || decimals < 0) {\n      decimals = 2;\n    }\n\n    \/\/ If user filled pg\/mL and left pmol\/L blank, convert pg\/mL -> pmol\/L\n    if (pgmlStr !== \"\" && pmolStr === \"\") {\n      const values = splitInput(pgmlStr);\n      const converted = values.map(val => {\n        const num = parseFloat(val);\n        if (isNaN(num)) return \"Invalid\";\n        \/\/ pg\/mL to pmol\/L\n        return (num * FACTOR_PG_TO_PMOL).toFixed(decimals);\n      });\n      pmolInput.value = converted.join(\"\\n\");\n    }\n    \/\/ If user filled pmol\/L and left pg\/mL blank, convert pmol\/L -> pg\/mL\n    else if (pmolStr !== \"\" && pgmlStr === \"\") {\n      const values = splitInput(pmolStr);\n      const converted = values.map(val => {\n        const num = parseFloat(val);\n        if (isNaN(num)) return \"Invalid\";\n        \/\/ pmol\/L to pg\/mL\n        return (num * FACTOR_PMOL_TO_PG).toFixed(decimals);\n      });\n      pgmlInput.value = converted.join(\"\\n\");\n    }\n    \/\/ If both or neither are filled, show a warning\n    else {\n      alert(\"Please fill in EITHER the pg\/mL box OR the pmol\/L box (not both).\");\n    }\n  }\n\n  \/**\n   * resetFields:\n   * Clears both textareas and the decimals input.\n   *\/\n  function resetFields() {\n    pgmlInput.value = \"\";\n    pmolInput.value = \"\";\n    decimalsInput.value = \"\";\n  }\n\n  \/**\n   * splitInput:\n   * Splits a string by commas, spaces, tabs, or new lines.\n   * Returns an array of trimmed values.\n   *\/\n  function splitInput(str) {\n    \/\/ Split on commas OR whitespace\n    return str.split(\/[\\s,]+\/).filter(Boolean);\n  }\n});\n<\/script>\n\n<\/body>\n<\/html>\n\n\n<h2><sub>What is ACTH?<\/sub><\/h2>\n<p>Adrenocorticotropic Hormone (ACTH, also known as Corticotropin) is the principal hormone required for the synthesis and secretion of adrenal glucocorticoids. ACTH is primarily synthesized by the anterior pitutiary gland and is composed of 39 amino acids. It is indeed part of a much larger amino acid precusor know as pro-opiomelanocortin POMC (a 241 aminoacid sequence).<\/p>\n<p>POMC is typically broken down in a tissue-specific manner to produce smaller peptide hormones. Firstly, Proprotein convertase 1, also known as prohormone convertase, \u00a0cleaves POMC into \u00a0\u03b2-lipoprotein (\u03b2-LPH) and pro-ACTH.<\/p>\n<p>The first 24 of 39 amino acids present in ACTH are common to all species and is responsible for most of the biological activity of this peptide hormone. Indeed a synthetic version of ACTH 1\u201324 (Synacthen\/Cortrosyn) is ubiquitously utilized in the field of <a href=\"https:\/\/myendoconsult.com\/learn\/dynamic-tests-in-endocrinology\/\">endocrinology for dynamic testing<\/a> of the the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis.<\/p>\n<p>Melanocyte-stimulating hormones (a, \u03b2, and \u03b3) are additional byproducts of the cleavage of POMC. As the name implies, MSH plays an important in the hyperpigmentation seen in patients with either Addison\u2019s disease or Nelson\u2019s syndrome. It is however worth noting that elevated levels of ACTH binding to the melanocortin-1 receptor (MCR-1) plays a significant role in the dark hue noted amongst lighter skinned individuals with this condition.<\/p>\n<h2><sub>Clinical application<\/sub><\/h2>\n<p>Cortrosyn stimulation test<\/p>\n<p><strong>Rationale\u00a0<\/strong><\/p>\n<p>A dynamic test for the evaluation of suspected <a href=\"https:\/\/myendoconsult.com\/learn\/primary-adrenal-insufficiency-sick-day-rules\/\">adrenal insufficiency<\/a>. The test cannot distinguish between primary and secondary AI<\/p>\n<p><strong>Limitations of this test<\/strong><\/p>\n<ul>\n<li>Estrogen in OCPs may increase corticosteroid-binding globulin and thus increase total serum cortisol.<\/li>\n<li>Low albumin can lead to a spuriously low serum cortisol<\/li>\n<li>It does not distinguish between primary and secondary AI (normal stimulation test if adrenocortical atrophy has not set in yet)<\/li>\n<\/ul>\n<p><strong>Procedure<\/strong><\/p>\n<ol>\n<li>Draw a baseline serum cortisol (at any time, need not be in the early morning)<\/li>\n<li>Inject 250mcg of Cosyntropin(Cortrosyn), IM or IV<\/li>\n<li>Draw serum cortisol (total) at 30 and 60 minutes<\/li>\n<\/ol>\n<p><strong>Interpretation<\/strong><\/p>\n<p>Peak serum cortisol &gt;18mcg\/dL or an increment of &gt;7mcg\/dL over the baseline cortisol level rules out adrenal insufficiency.***<\/p>\n<p>*** Update : Newer cortisol assays, a level of &gt;14mcg\/dl effectively rules out AI<\/p>","protected":false},"excerpt":{"rendered":"<p>ACTH pg\/mL \u2194 pmol\/L Convertor Corticotropin (ACTH) Convertor pg\/mL \u2194 pmol\/L Enter values in pg\/mL or in pmol\/L, then click Calculate. You may convert multiple values at once by separating them with commas, spaces, tabs, or new lines. Corticotropin (ACTH) pg\/mL Corticotropin (ACTH) pmol\/L Decimals (e.g., 2) Calculate Reset Conversion Factors: 1 pg\/mL = 0.22 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[100],"tags":[],"class_list":["post-3572804","post","type-post","status-publish","format-standard","hentry","category-endocalculator","post-wrapper","thrv_wrapper"],"_links":{"self":[{"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/posts\/3572804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/comments?post=3572804"}],"version-history":[{"count":28,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/posts\/3572804\/revisions"}],"predecessor-version":[{"id":4421964,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/posts\/3572804\/revisions\/4421964"}],"wp:attachment":[{"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/media?parent=3572804"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/categories?post=3572804"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/tags?post=3572804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}