{"id":870839,"date":"2022-02-07T23:47:56","date_gmt":"2022-02-08T04:47:56","guid":{"rendered":"https:\/\/myendoconsult.com\/learn\/?p=870839"},"modified":"2023-03-16T05:49:45","modified_gmt":"2023-03-16T10:49:45","slug":"ldl-calculator","status":"publish","type":"post","link":"https:\/\/myendoconsult.com\/learn\/ldl-calculator\/","title":{"rendered":"LDL calculator"},"content":{"rendered":"<p>This calculator for estimating LDL cholesterol is based on the <strong>Friedewald equation<\/strong>. Enter lipid values in either <strong>mg\/dL<\/strong> or <strong>mmol\/L<\/strong> to calculate low-density cholesterol (LDL).<\/p>\n<h2>The Friedewald equation in mg\/dL<\/h2>\n<div class='fluentform ff-default fluentform_wrapper_18 ffs_modern_b_wrap'><form data-form_id=\"18\" id=\"fluentform_18\" class=\"frm-fluent-form fluent_form_18 ff-el-form-top ff_form_instance_18_1 ff-form-loading ff_calc_form ffs_modern_b\" data-form_instance=\"ff_form_instance_18_1\" method=\"POST\" ><fieldset  style=\"border: none!important;margin: 0!important;padding: 0!important;background-color: transparent!important;box-shadow: none!important;outline: none!important; min-inline-size: 100%;\">\n                    <legend class=\"ff_screen_reader_title\" style=\"display: block; margin: 0!important;padding: 0!important;height: 0!important;text-indent: -999999px;width: 0!important;overflow:hidden;\">LDL cholesterol calculator (#18)<\/legend>        <div\n                style=\"display: none!important; position: absolute!important; transform: translateX(1000%)!important;\"\n                class=\"ff-el-group ff-hpsf-container\"\n        >\n            <div class=\"ff-el-input--label asterisk-right\">\n                <label for=\"ff_18_item_sf\" aria-label=\"Contact\">\n                    Contact                <\/label>\n            <\/div>\n            <div class=\"ff-el-input--content\">\n                <input type=\"text\"\n                       name=\"item_18__fluent_sf\"\n                       class=\"ff-el-form-control\"\n                       id=\"ff_18_item_sf\"\n                \/>\n            <\/div>\n        <\/div>\n        <input type='hidden' name='__fluent_form_embded_post_id' value='870839' \/><input type=\"hidden\" id=\"_fluentform_18_fluentformnonce\" name=\"_fluentform_18_fluentformnonce\" value=\"2a0c002c80\" \/><input type=\"hidden\" name=\"_wp_http_referer\" value=\"\/learn\/wp-json\/wp\/v2\/posts\/870839\" \/><div class='ff-el-group'><div class=\"ff-el-input--label ff-el-is-required asterisk-right\"><label for='ff_18_total_cholesterol' id='label_ff_18_total_cholesterol' aria-label=\"Total Cholesterol\">Total Cholesterol<\/label><\/div><div class='ff-el-input--content'><input type=\"number\" name=\"total_cholesterol\" id=\"ff_18_total_cholesterol\" class=\"ff-el-form-control\" placeholder=\"normal range 150-200 (value in mg\/dL)\" data-name=\"total_cholesterol\" inputmode=\"numeric\" step=\"any\"  aria-invalid=\"false\" aria-required=true><\/div><\/div><div class='ff-el-group'><div class=\"ff-el-input--label ff-el-is-required asterisk-right\"><label for='ff_18_HDL_Cholester' id='label_ff_18_HDL_Cholester' aria-label=\"HDL Cholesterol\">HDL Cholesterol<\/label><\/div><div class='ff-el-input--content'><input type=\"number\" name=\"HDL_Cholester\" id=\"ff_18_HDL_Cholester\" class=\"ff-el-form-control\" placeholder=\"normal range 40-60 (value in mg\/dL)\" data-name=\"HDL_Cholester\" inputmode=\"numeric\" step=\"any\"  aria-invalid=\"false\" aria-required=true><\/div><\/div><div class='ff-el-group'><div class=\"ff-el-input--label ff-el-is-required asterisk-right\"><label for='ff_18_triglycerides' id='label_ff_18_triglycerides' aria-label=\"Triglycerides\">Triglycerides<\/label><\/div><div class='ff-el-input--content'><input type=\"number\" name=\"triglycerides\" id=\"ff_18_triglycerides\" class=\"ff-el-form-control\" placeholder=\"normal range 0-150 (value in mg\/dL)\" data-name=\"triglycerides\" inputmode=\"numeric\" step=\"any\"  aria-invalid=\"false\" aria-required=true><\/div><\/div><div class='ff-el-group'><div class=\"ff-el-input--label asterisk-right\"><label for='ff_18_numeric_field_10' id='label_ff_18_numeric_field_10' aria-label=\"Estimated LDL cholesterol (mg per dL)\">Estimated LDL cholesterol (mg per dL)<\/label><\/div><div class='ff-el-input--content'><input type=\"text\" name=\"numeric_field_10\" id=\"ff_18_numeric_field_10\" class=\"ff-el-form-control  ff_has_formula\" data-name=\"numeric_field_10\" data-calculation_formula=\"{input.total_cholesterol}-{input.HDL_Cholester}-({input.triglycerides} \/ 5)\" readonly=\"1\"  aria-invalid=\"false\" aria-required=false><\/div><\/div><div class='ff-el-group ff-text-left ff_submit_btn_wrapper'><button type=\"submit\" class=\"ff-btn ff-btn-submit ff-btn-lg ff_btn_style\"  aria-label=\"Calculate\">Calculate<\/button><\/div><\/fieldset><\/form><div id='fluentform_18_errors' class='ff-errors-in-stack ff_form_instance_18_1 ff-form-loading_errors ff_form_instance_18_1_errors'><\/div><\/div>            <script type=\"text\/javascript\">\n                window.fluent_form_ff_form_instance_18_1 = {\"id\":\"18\",\"ajaxUrl\":\"https:\\\/\\\/myendoconsult.com\\\/learn\\\/wp-admin\\\/admin-ajax.php\",\"settings\":{\"layout\":{\"labelPlacement\":\"top\",\"helpMessagePlacement\":\"with_label\",\"errorMessagePlacement\":\"inline\",\"asteriskPlacement\":\"asterisk-right\"},\"restrictions\":{\"denyEmptySubmission\":{\"enabled\":false}}},\"form_instance\":\"ff_form_instance_18_1\",\"form_id_selector\":\"fluentform_18\",\"rules\":{\"total_cholesterol\":{\"required\":{\"value\":true,\"message\":\"This field is required\"},\"numeric\":{\"value\":true,\"message\":\"This field must contain numeric value\"},\"min\":{\"value\":\"\",\"message\":\"Minimum value is \"},\"max\":{\"value\":\"\",\"message\":\"Maximum value is \"}},\"HDL_Cholester\":{\"required\":{\"value\":true,\"message\":\"This field is required\"},\"numeric\":{\"value\":true,\"message\":\"This field must contain numeric value\"},\"min\":{\"value\":\"\",\"message\":\"Minimum value is \"},\"max\":{\"value\":\"\",\"message\":\"Maximum value is \"}},\"triglycerides\":{\"required\":{\"value\":true,\"message\":\"This field is required\"},\"numeric\":{\"value\":true,\"message\":\"This field must contain numeric value\"},\"min\":{\"value\":\"\",\"message\":\"Minimum value is \"},\"max\":{\"value\":\"\",\"message\":\"Maximum value is \"}},\"numeric_field_10\":{\"required\":{\"value\":false,\"message\":\"This field is required\"},\"numeric\":{\"value\":true,\"message\":\"This field must contain numeric value\"},\"min\":{\"value\":\"\",\"message\":\"Minimum value is \"},\"max\":{\"value\":\"\",\"message\":\"Maximum value is \"}}},\"debounce_time\":300};\n                            <\/script>\n            \n<h2>The Friedewald equation in mmol\/L units.<\/h2>\n<div class='fluentform ff-default fluentform_wrapper_19 ffs_modern_b_wrap'><form data-form_id=\"19\" id=\"fluentform_19\" class=\"frm-fluent-form fluent_form_19 ff-el-form-top ff_form_instance_19_2 ff-form-loading ff_calc_form ffs_modern_b\" data-form_instance=\"ff_form_instance_19_2\" method=\"POST\" ><fieldset  style=\"border: none!important;margin: 0!important;padding: 0!important;background-color: transparent!important;box-shadow: none!important;outline: none!important; min-inline-size: 100%;\">\n                    <legend class=\"ff_screen_reader_title\" style=\"display: block; margin: 0!important;padding: 0!important;height: 0!important;text-indent: -999999px;width: 0!important;overflow:hidden;\">LDL cholesterol calculator (#19)<\/legend>        <div\n                style=\"display: none!important; position: absolute!important; transform: translateX(1000%)!important;\"\n                class=\"ff-el-group ff-hpsf-container\"\n        >\n            <div class=\"ff-el-input--label asterisk-right\">\n                <label for=\"ff_19_item_sf\" aria-label=\"Newsletter\">\n                    Newsletter                <\/label>\n            <\/div>\n            <div class=\"ff-el-input--content\">\n                <input type=\"text\"\n                       name=\"item_19__fluent_sf\"\n                       class=\"ff-el-form-control\"\n                       id=\"ff_19_item_sf\"\n                \/>\n            <\/div>\n        <\/div>\n        <input type='hidden' name='__fluent_form_embded_post_id' value='870839' \/><input type=\"hidden\" id=\"_fluentform_19_fluentformnonce\" name=\"_fluentform_19_fluentformnonce\" value=\"2a0c002c80\" \/><input type=\"hidden\" name=\"_wp_http_referer\" value=\"\/learn\/wp-json\/wp\/v2\/posts\/870839\" \/><div class='ff-el-group'><div class=\"ff-el-input--label ff-el-is-required asterisk-right\"><label for='ff_19_2_total_cholesterol' id='label_ff_19_2_total_cholesterol' aria-label=\"Total Cholesterol\">Total Cholesterol<\/label><\/div><div class='ff-el-input--content'><input type=\"text\" name=\"total_cholesterol\" id=\"ff_19_2_total_cholesterol\" class=\"ff-el-form-control  ff_numeric\" placeholder=\"normal range 3.9 - 5.2 (value in mmol\/L)\" data-name=\"total_cholesterol\" inputmode=\"numeric\" step=\"any\" data-formatter=\"{&quot;decimal&quot;:&quot;.&quot;,&quot;separator&quot;:&quot;,&quot;,&quot;precision&quot;:2,&quot;symbol&quot;:&quot;&quot;}\"  aria-invalid=\"false\" aria-required=true><\/div><\/div><div class='ff-el-group'><div class=\"ff-el-input--label ff-el-is-required asterisk-right\"><label for='ff_19_2_HDL_Cholester' id='label_ff_19_2_HDL_Cholester' aria-label=\"HDL Cholesterol\">HDL Cholesterol<\/label><\/div><div class='ff-el-input--content'><input type=\"number\" name=\"HDL_Cholester\" id=\"ff_19_2_HDL_Cholester\" class=\"ff-el-form-control\" placeholder=\"normal range 1.0 - 1.6 (value in mmol\/L)\" data-name=\"HDL_Cholester\" inputmode=\"numeric\" step=\"any\"  aria-invalid=\"false\" aria-required=true><\/div><\/div><div class='ff-el-group'><div class=\"ff-el-input--label ff-el-is-required asterisk-right\"><label for='ff_19_2_triglycerides' id='label_ff_19_2_triglycerides' aria-label=\"Triglycerides\">Triglycerides<\/label><\/div><div class='ff-el-input--content'><input type=\"number\" name=\"triglycerides\" id=\"ff_19_2_triglycerides\" class=\"ff-el-form-control\" placeholder=\"normal range 0 - 1.7 (value in mmol\/L)\" data-name=\"triglycerides\" inputmode=\"numeric\" step=\"any\"  aria-invalid=\"false\" aria-required=true><\/div><\/div><div class='ff-el-group'><div class=\"ff-el-input--label asterisk-right\"><label for='ff_19_2_numeric_field_10' id='label_ff_19_2_numeric_field_10' aria-label=\"Estimated LDL cholesterol (mg per dL)\">Estimated LDL cholesterol (mg per dL)<\/label><\/div><div class='ff-el-input--content'><input type=\"text\" name=\"numeric_field_10\" id=\"ff_19_2_numeric_field_10\" class=\"ff-el-form-control  ff_has_formula ff_numeric\" data-name=\"numeric_field_10\" data-calculation_formula=\"{input.total_cholesterol}-{input.HDL_Cholester}-({input.triglycerides} \/ 2.17)\" readonly=\"1\" data-formatter=\"{&quot;decimal&quot;:&quot;,&quot;,&quot;separator&quot;:&quot;.&quot;,&quot;precision&quot;:2,&quot;symbol&quot;:&quot;&quot;}\"  aria-invalid=\"false\" aria-required=false><\/div><\/div><div class='ff-el-group ff-text-left ff_submit_btn_wrapper'><button type=\"submit\" class=\"ff-btn ff-btn-submit ff-btn-lg ff_btn_style\"  aria-label=\"Calculate\">Calculate<\/button><\/div><\/fieldset><\/form><div id='fluentform_19_errors' class='ff-errors-in-stack ff_form_instance_19_2 ff-form-loading_errors ff_form_instance_19_2_errors'><\/div><\/div>            <script type=\"text\/javascript\">\n                window.fluent_form_ff_form_instance_19_2 = {\"id\":\"19\",\"ajaxUrl\":\"https:\\\/\\\/myendoconsult.com\\\/learn\\\/wp-admin\\\/admin-ajax.php\",\"settings\":{\"layout\":{\"labelPlacement\":\"top\",\"helpMessagePlacement\":\"with_label\",\"errorMessagePlacement\":\"inline\",\"asteriskPlacement\":\"asterisk-right\"},\"restrictions\":{\"denyEmptySubmission\":{\"enabled\":false}}},\"form_instance\":\"ff_form_instance_19_2\",\"form_id_selector\":\"fluentform_19\",\"rules\":{\"total_cholesterol\":{\"required\":{\"value\":true,\"message\":\"This field is required\"},\"numeric\":{\"value\":true,\"message\":\"This field must contain numeric value\"},\"min\":{\"value\":\"\",\"message\":\"Minimum value is \"},\"max\":{\"value\":\"\",\"message\":\"Maximum value is \"}},\"HDL_Cholester\":{\"required\":{\"value\":true,\"message\":\"This field is required\"},\"numeric\":{\"value\":true,\"message\":\"This field must contain numeric value\"},\"min\":{\"value\":\"\",\"message\":\"Minimum value is \"},\"max\":{\"value\":\"\",\"message\":\"Maximum value is \"}},\"triglycerides\":{\"required\":{\"value\":true,\"message\":\"This field is required\"},\"numeric\":{\"value\":true,\"message\":\"This field must contain numeric value\"},\"min\":{\"value\":\"\",\"message\":\"Minimum value is \"},\"max\":{\"value\":\"\",\"message\":\"Maximum value is \"}},\"numeric_field_10\":{\"required\":{\"value\":false,\"message\":\"This field is required\"},\"numeric\":{\"value\":true,\"message\":\"This field must contain numeric value\"},\"min\":{\"value\":\"\",\"message\":\"Minimum value is \"},\"max\":{\"value\":\"\",\"message\":\"Maximum value is \"}}},\"debounce_time\":300};\n                            <\/script>\n            \n<h2>Application<\/h2>\n<p>Routine <a href=\"https:\/\/myendoconsult.com\/learn\/types-of-hyperlipidemia\/\">lipid<\/a> panels measure direct total cholesterol, HDL cholesterol, and triglycerides. LDL cholesterol is, however, estimated indirectly using the Friedewald equation. This equation was developed in 1972 using samples from just 448 subjects. Interestingly, the equation has gained wide acceptance in clinical medicine for several decades.<\/p>\n<h2>Limitations<\/h2>\n<p>Lipid panel should be ordered after an overnight fast. In addition, the Friedewald equation performs poorly as an estimate of <a href=\"https:\/\/myendoconsult.com\/learn\/cholesterol-synthesis-pathway\/\">LDL cholesterol<\/a> for patients with significant hypertriglyceridemia or very low LDL cholesterol. In this scenario, direct LDL cholesterol estimation by beta quantification is recommended.<\/p>\n<p>Other equations have been recently reported in the literature. For example, the Martin-Hopkins equation is accurate for LDL cholesterol levels below 70mg\/dL. On the other hand, the National Institutes of Health equation (by Sampson et al.) is most accurate in the setting of triglyceride levels above 400mg\/dL.<\/p>\n<h2>References<\/h2>\n<ul>\n<li>Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/4337382\/\" target=\"_blank\" rel=\"noopener\">Clin Chem 1972;18:499-502.<\/a><\/li>\n<\/ul>\n<ul>\n<li>Martin SS, Blaha MJ, Elshazly MB, et al. Comparison of a novel method vs the Friedewald equation for estimating low-density lipoprotein cholesterol levels from the standard lipid profile.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24240933\/\" target=\"_blank\" rel=\"noopener\"> JAMA 2013;310:2061-68.<\/a><\/li>\n<\/ul>\n<ul>\n<li>Sampson M, Ling C, Sun Q et al. A new equation for calculation of low-density lipoprotein cholesterol in patients with normolipidemia and\/or hypertriglyceridemia. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32101259\/\" target=\"_blank\" rel=\"noopener\">JAMA Cardiol Published online Feb 2020.<\/a><\/li>\n<\/ul>\n<ul>\n<li>Song, Y., Lee, H.S., Baik, S.J. <em>et al.<\/em> Comparison of the effectiveness of Martin\u2019s equation, Friedewald\u2019s equation, and a Novel equation in low-density lipoprotein cholesterol estimation. <a href=\"https:\/\/doi.org\/10.1038\/s41598-021-92625-x\" target=\"_blank\" rel=\"noopener\"><em>Sci Rep<\/em><strong>11, <\/strong>13545 (2021)<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>This calculator for estimating LDL cholesterol is based on the Friedewald equation. Enter lipid values in either mg\/dL or mmol\/L to calculate low-density cholesterol (LDL). The Friedewald equation in mg\/dL The Friedewald equation in mmol\/L units. Application Routine lipid panels measure direct total cholesterol, HDL cholesterol, and triglycerides. LDL cholesterol is, however, estimated indirectly using [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[100],"tags":[],"class_list":["post-870839","post","type-post","status-publish","format-standard","hentry","category-endocalculator","post-wrapper","thrv_wrapper"],"_links":{"self":[{"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/posts\/870839","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/comments?post=870839"}],"version-history":[{"count":42,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/posts\/870839\/revisions"}],"predecessor-version":[{"id":4415906,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/posts\/870839\/revisions\/4415906"}],"wp:attachment":[{"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/media?parent=870839"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/categories?post=870839"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/myendoconsult.com\/learn\/wp-json\/wp\/v2\/tags?post=870839"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}