What is a Landmark Trial?

A short course about landmark trials in clinical endocrinology

Landmark clinical trials are practice-changing and highly influential studies that either caused a paradigm shift in medical practice or clarified previously unclear answers to critical questions in medical management.

Additional attributes of landmark clinical trials include the following

– Long term relevance in the medical community

– Frequently cited in academic texts and guidelines

– Challenged conventional medical management, leading to a change in practice, i.e., “practice-changing.”