Comprehensive MCQs dedicated to pituitary gland physiology and relevant clinical correlates.
Normal Laboratory Reference values
Laboratory Test | Normal Range in US Units | Normal Range in SI Units | To Convert U.S. to SI Units |
ALT (Alanine aminotransferase) | F 7-30 units/L | F 0.12-0.50 µkat/L | x 0.01667 |
M 10-55 units/L | M 0.17-0.92 µkat/L | ||
Albumin | 3.1 – 4.3 g/dL | 31 – 43 g/L | x 10 |
Alkaline Phosphatase | F 30-100 units/L M 45-115 units/L | F 0.5-1.67 µkat/L M 0.75-1.92 µkat/L | x 0.01667 |
Amylase (Serum) | 53-123 units/L | 0.88-2.05 nkat/L | x 0.01667 |
AST (Aspartate aminotransferase) | F 9-25 units/L | F 0.15-0.42 µkat/L | x 0.01667 |
M 10-40 units/L | M 0.17-0.67 µkat/L | ||
Basophils | 0-3% of lymphocytes | 0.0-0.03 fraction of white blood cells | x 0.01 |
Bilirubin – Direct | 0.0-0.4 mg/dL | 0-7 µmol/L | x 17.1 |
Bilirubin – Total | 0.0-1.0 mg/dL | 0-17 µmol/L | |
Blood pressure | Normal: 120/70 to 120/80 millimeters of mercury (mmHg). Top number is systolic pressure, when heart is pumping. Bottom number is diastolic pressure when heart is at rest. Blood pressure can be too low (hypotension) or too high (hypertension). | No conversion | |
C peptide | 0.5-2.0 ng/mL | 0.17-0.66 nmol/L | x 0.33 |
Calcium, serum | 8.5-10.5 mg/dL | 2.1-2.6 mmol/L | x 0.25 |
Calcium, urine | 0-300 mg/24hr | 0.0-7.5 mmol/24hr | x 0.025 |
CO2 (Bicarbonate) | 20-32 mmol/L | 20-32 mmol/L | No conversion |
Chloride | 95-108 mmol/L | 95-108 mmol/L | No conversion |
Cholesterol, Total | <200 mg/dL | <5.17 mmol/L | x 0.02586 |
Marginal | 200-239 mg/dL | 5.17-6.18 mmol/L | |
High | >239 mg/dl | >6.18 mmol/L | |
Cholesterol, LDL | <100 mg/dL | <2.59 mmol/L | |
Marginal | 100-159 mg/dL | 2.59-4.14 mmol/L | |
High | 160-189 mg/dL | 4.14 – 4.89 mmol/L | |
Very High | >190 mg/dL | >4.91 mmol/L | |
Cholesterol, HDL | >60 mg/dL | >1.55 mmol/L | |
Moderate | 40-60 mg/dL | 1.03-1.55 mmol/L | |
Low (heart risk) | <40 mg/dL | <1.03 mmol/L | |
Cortisol: serum free (urine) | 0-25 µg/dL (depends on time of day) | 0-690 nmol/L | x 27.59 |
20-70 µg/dL | 55-193 nmol/24hr | x 2.759 | |
Creatine kinase | F 40-150 units/L M 60-400 units/L | F 0.67-2.50 µkat/L M 1.00-6.67 µkat/L | x 0.01667 |
Creatinine (urine) | F 0.6-1.8 g/day M 0.8-2.4 g/day | F 5.3-15.9 mmol/day M 7.1-21.2 mmol/day | x 88.4 |
DHEA | F 130-980 ng/dL M 180-1250 ng/dL | F 4.5-34.0 nmol/L M 6.24-43.3 nmol/L | x 0.03467 |
DHEA Sulfate | F Pre-menopause: 12-535 µg/dL | F Pre-menopause: 120-5350 µg/L | x 10 |
F Post-menopause: 30-260 µg/dL | F Post-menopause: 300-2600 µg/L | ||
M 10-619 µg/dL | M 100-6190 µg/L | ||
Eosinophils | 0-8% of white blood cells | 0.0-0.8 fraction of white blood cells | x 0.01 |
Erythrocyte sedimentation rate (Sed Rate) | F £ 30 mm/h M £ 20 mm/h | F £ 30 mm/h M £ 20 mm/h | No conversion |
Folate | 3.1-17.5 ng/mL | 7.0-39.7 nmol/L | x 2.266 |
Glucose, urine | <0.05 g/dl | <0.003 mmol/L | x 0.05551 |
Glucose, plasma | 70-110 mg/dL | 3.9-6.1 mmol/L | |
Gamma glutamyl transferase (GGT) | F £ 45 U/L M £ 65 U/L | F £ 45 U/L M £ 65 U/L | No conversion |
Laboratory Test | Normal Range in U.S. Units | Normal Range in SI Units | To Convert US to SI Units |
Hematocrit | F 36.0-46.0% of red blood cells | F 0.36-0.46 fraction of red blood cells | x 0.01 |
M 37.0-49.0% of red blood cells | M 0.37-0.49 fraction of red blood cells | ||
Hemoglobin | F 12.0-16.0 g/dL M 13.0-18.0 g/dL | F 7.4-9.9 mmol/L M 8.1-11.2 mmol/L | x 0.6206 |
Lactate dehydrogenase (LDH) (total) | £ 270 U/L | £ 4.5 µkat/L | X 0.016667 |
Lactic acid | 0.5-2.2 mmol/L | 0.5-2.2 mmol/L | No conversion |
Leukocytes (WBC) | 4.5-11.0 x 103/mm3 | 4.5-11.0 x 109/liter | No conversion |
Lymphocytes | 16-46% of white blood cells | 0.16-0.46 fraction of white blood cells | x 0.01 |
Mean corpuscular hemoglobin (MCH) | 25.0-35.0 pg/cell | 25.0-35.0 pg/cell | No conversion |
Mean corpuscular hemoglobin concentration (MCHC) | 31.0-37.0 g/dL | 310-370 g/L | x 10 |
Mean corpuscular volume (MCV) | F 78-102 µm3 M 78-100 µm3 | F 78-102 fl M 78-100 fl | No conversion |
Monocytes | 4-11% of white blood cells | 0.04-0.11 fraction of white blood cells | x 0.01 |
Neutrophils | 45-75% of white blood cells | 0.45-0.75 fraction of white blood cells | x 0.01 |
Phosphorus | 2.5-4.5 mg/dL | 0.81-1.45 mmol/L | X 0.323 |
Platelets (Thrombocytes) | 130-400 x 103/µL | 130-400 x 109/L | No conversion |
Potassium | 3.4-5.0 mmol/L | 3.4-5.0 mmol/liter | No conversion |
Red Blood Cell Count (RBC) | F 3.9-5.2 x 106/µL M 4.4–5.8 x 106/µL | F 3.9-5.2 x 1012/L M W 4.4-5.8 x 1012/L | No conversion |
Sodium | 135-145 mmol/liter | 135-145 mmol/liter | No conversion |
Testosterone, total (morning sample) | F 6-86 ng/dL | F 0.21-2.98 nmol/liter | x 0.03467 |
M 270-1070 ng/dL | M 9.36-37.10 nmol/liter | ||
Testosterone, Age 20-40 Unbound Age 41-60 Age 61-80 | F 0.6-3.1 pg/mL M 15.0-40.0 pg/mL | F 20.8-107.5 pmol/liter M 520-1387 pmol/liter | x 34.67 |
F 0.4-2.5 pg/mL M 13.0-35.0 pg/mL | F 13.9-86.7 pmol/liter M 451-1213 pmol/liter | ||
F 0.2-2.0 pg/mL M 12.0-28.0 pg/mL | F 6.9-69.3 pmol/liter M 416-971 pmol/liter | ||
Triglycerides Normal (fasting) Borderline High Very High | 40-150 mg/dL 150-200 mg/dL 200-500 mg/dL >500 mg/dL | 0.45-1.69 mmol/liter 1.69-2.26 mmol/liter 2.26-5.65 mmol/liter >5.65 mmol/liter | x 0.01129 |
Urea, plasma (BUN) | 8-25 mg/dL | 2.9-8.9 mmol/liter | x 0.357 |
Urinalysis: pH Specific gravity | 5.0-9.0 | 5.0-9.0 | No conversion |
1.001-1.035 | 1.001-1.035 | ||
WBC (White blood cells, Leukocytes) | 4.5-11.0 x 103/mm3 | 4.5-11.0 x 109/liter | No conversion |
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Category: Basic Science Endocrinology
Q: What part of the brain is the hypothalamus connected to?
Consider the role of the hypothalamus in regulating the internal environment and its connection to the endocrine system.Q: What is the median eminence in the hypothalamus?
Category: Basic Science Endocrinology
Which of the following is NOT a direct effect of prolactin on the reproductive axis in humans?
Consider which effect of prolactin is specific to certain mammals and not humans.
Category: Basic Science Endocrinology
What is the primary cause of infertility in both men and women with hyperprolactinaemia?
Consider the effect of hyperprolactinaemia on LH release.
Category: Basic Science Endocrinology
Which hormone inhibits prolactin release via D2 receptors?
Consider the hormone that has a dominant inhibitory effect on prolactin release.
Category: Basic Science Endocrinology
Which of the following hormones is NOT a glycoprotein hormone?
Recall which hormones are part of the glycoprotein hormone family.
Category: Basic Science Endocrinology
A 35-year-old woman presents to her physician with complaints of irregular menstrual cycles and difficulty getting pregnant. Her physical examination is unremarkable, and her labs show elevated LH and normal FSH levels. What is the most likely cause of her symptoms?
Elevated LH levels and irregular menstrual cycles are commonly seen in this condition, which affects women of reproductive age.
Category: Basic Science Endocrinology
A 25-year-old male presents with infertility issues and low testosterone levels. He has a history of delayed puberty. Labs show decreased LH and FSH levels. What is the most likely cause of his symptoms?
Low LH and FSH levels with low testosterone levels are characteristic of this condition, which affects the hypothalamic-pituitary-gonadal axis.
Category: Basic Science Endocrinology
A 42-year-old woman presents with hot flashes, night sweats, and irregular periods. Her FSH and LH levels are found to be elevated. What is the most likely diagnosis?
Elevated FSH and LH levels with symptoms of hot flashes and night sweats indicate a decline in ovarian function, which occurs earlier than expected in this condition.
Category: Basic Science Endocrinology
A 30-year-old woman with a history of irregular menstrual cycles undergoes hormonal evaluation. Her labs reveal elevated prolactin levels and decreased FSH and LH levels. What is the most likely cause of her symptoms?
Elevated prolactin levels with decreased FSH and LH levels can disrupt the menstrual cycle and are characteristic of this condition.
Category: Basic Science Endocrinology
Which hormone has a direct inhibitory effect on the synthesis of the TSH β-subunit?
Inhibition of TSH synthesis
Category: Basic Science Endocrinology
Which of the following actions is NOT directly stimulated by thyrotropin (TSH)?
TSH actions on follicular cells
Category: Basic Science Endocrinology
Which hormone is responsible for the stimulatory effect on thyrotrophin production indirectly via stimulation of TRH release from the hypothalamus?
Effect of peripheral hormones on thyrotrophin production
Category: Basic Science Endocrinology
Which second messenger system is involved in the action of TRH on its target cells?
TRH receptor signaling
Category: Basic Science Endocrinology
A 35-year-old female presents with symptoms of fatigue, weight gain, and cold intolerance. Laboratory results show decreased serum T3 and T4 levels and increased TSH levels. Which of the following best describes the mechanism of negative feedback involved in this case?
Consider the role of T3 and T4 in the negative feedback mechanism.
Category: Basic Science Endocrinology
A 45-year-old male presents with a history of recurrent infections, fatigue, and weight loss. Laboratory results show decreased serum cortisol and ACTH levels. Which of the following is most likely responsible for the patient's symptoms?
Consider the role of ACTH in the regulation of cortisol production.
Category: Basic Science Endocrinology
In a patient with Cushing's disease, which hormone is most likely responsible for causing hyperpigmentation of the skin?
Consider the hormone responsible for binding to melanocortin receptors on melanocytes.
Category: Basic Science Endocrinology
Which of the following hormones has a direct negative feedback effect on ACTH production by acting on the adenohypophysial corticotrophs and an indirect negative feedback effect on the hypothalamic neurons producing CRH?
Consider the hormone that influences both ACTH production and CRH release.
Category: Basic Science Endocrinology
Which of the following stressors would most likely activate the hypothalamo-pituitary-adrenal (HPA) axis and increase the circulating levels of ACTH and cortisol?
Consider the various stressors that can activate the HPA axis.
Category: Basic Science Endocrinology
Which of the following conditions is associated with raised ACTH and cortisol levels in circulation, as well as a loss of the normal circadian rhythm of release?
Consider the condition related to emotional and mental well-being.
Category: Basic Science Endocrinology
Exercise is a potent stimulus for the release of which hormone?
Consider the hormone that responds to physical stressors such as exercise.
Category: Basic Science Endocrinology
What is the most common gold standard test for diagnosing Growth Hormone (GH) deficiency?
This test involves inducing hypoglycaemia.
Category: Basic Science Endocrinology
What is the primary function of Gonadotrophins (LH and FSH) in females?
These hormones are involved in the menstrual cycle.
Category: Basic Science Endocrinology
What is the usual cause of a rise in circulating prolactin levels in the context of a pituitary tumor?
This hormone is normally under tonic inhibition from the hypothalamus.
Category: Basic Science Endocrinology
What is the primary treatment for testosterone deficiency in men?
This treatment involves replacing the deficient hormone.
Category: Basic Science Endocrinology
In patients with anterior pituitary hypofunction, which hormone should be replaced first?
This hormone is essential for stress response and metabolism.
Category: Basic Science Endocrinology
What is the size limit that differentiates a pituitary microadenoma from a macroadenoma?
The difference is in their diameter.
Category: Basic Science Endocrinology
What type of pituitary tumor specifically produces excess quantities of ACTH, leading to Cushing's disease?
This tumor affects the secretion of ACTH.
Category: Basic Science Endocrinology
What are the two main clinical features of prolactinomas in women?
These features are related to milk production and menstruation.
Category: Basic Science Endocrinology
What is the best time to measure cortisol concentration when suspecting Cushing's disease?
Cortisol levels should be low during this time.
Category: Basic Science Endocrinology
Which type of pituitary tumor is most likely to cause hypopituitarism despite staining for gonadotrophins?
Category: Basic Science Endocrinology
What is the most common cause of the syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH)?
SIADH is most commonly not truly a pituitary problem.
Category: Basic Science Endocrinology
Which of the following is not a treatment option for acromegaly?
Dopamine agonists are used in the treatment of prolactinomas.
Category: Basic Science Endocrinology
What is a key diagnostic test to distinguish primary thyroid disease from a TSHoma?
This test involves the response to TRH.
Category: Basic Science Endocrinology
What is the primary cause of central diabetes insipidus?
This condition is related to the posterior pituitary gland.
Category: Basic Science Endocrinology
What type of pituitary tumor secretes excess growth hormone (GH)?
Category: Basic Science Endocrinology
Which hormone is primarily responsible for the milk production in lactating women?
This hormone is secreted by lactotroph cells in the anterior pituitary gland.
Category: Basic Science Endocrinology
Which of the following is not a common cause of hyperprolactinemia?
This condition is related to the posterior pituitary gland.
Category: Basic Science Endocrinology
What is the most common pituitary tumor in women?
This tumor is associated with the hormone responsible for milk production in lactating women.
Category: Basic Science Endocrinology
What is the most effective treatment for prolactinomas?
This treatment option includes drugs such as cabergoline and bromocriptine.
Category: Basic Science Endocrinology
In adults with excess growth hormone (GH) secretion, what is the resulting condition called?
This condition leads to enlarged hands, feet, and facial features.
Category: Basic Science Endocrinology
Which hormone does the syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH) involve?
Category: Basic Science Endocrinology
Which hormone is primarily responsible for the milk production in lactating women?
This hormone is secreted by lactotroph cells in the anterior pituitary gland.
Category: Basic Science Endocrinology
Which of the following is not a common cause of hyperprolactinemia?
This condition is related to the posterior pituitary gland.
Category: Basic Science Endocrinology
What is the most common pituitary tumor in women?
This tumor is associated with the hormone responsible for milk production in lactating women.
Category: Basic Science Endocrinology
What is the most effective treatment for prolactinomas?
This treatment option includes drugs such as cabergoline and bromocriptine.
Category: Basic Science Endocrinology
In adults with excess growth hormone (GH) secretion, what is the resulting condition called?
This condition leads to enlarged hands, feet, and facial features.
Category: Basic Science Endocrinology
Which hormone does the syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH) involve?
Category: Basic Science Endocrinology
Which part of the brain is responsible for regulating the release of hormones from the anterior pituitary gland?
This part of the brain is located just above the pituitary gland.
Category: Basic Science Endocrinology
What is the primary function of antidiuretic hormone (ADH)?
This hormone helps to concentrate urine by increasing water reabsorption in the kidneys.
Category: Basic Science Endocrinology
Which hormone is secreted by the hypothalamus to stimulate the release of growth hormone (GH) from the anterior pituitary gland?
This hormone specifically targets the release of GH.
Category: Basic Science Endocrinology
What is the primary target organ of adrenocorticotropic hormone (ACTH)?
This organ is located on top of the kidneys.
Category: Basic Science Endocrinology
Which hormone does the hypothalamus secrete to inhibit the release of prolactin from the anterior pituitary gland?
This hormone is also a neurotransmitter.
Category: Basic Science Endocrinology
How does the hypothalamus primarily communicate with the posterior pituitary gland?
The communication between these two structures is facilitated by axons of neurosecretory cells.
Category: Basic Science Endocrinology
Which hypothalamic nucleus is primarily responsible for synthesizing and releasing oxytocin?
This nucleus is involved in regulating various autonomic and neuroendocrine functions.
Category: Basic Science Endocrinology
In the context of the hypothalamic-pituitary-adrenal (HPA) axis, what is the primary function of cortisol?
Cortisol acts as a negative feedback regulator in the HPA axis.
Category: Basic Science Endocrinology
Which of the following conditions could potentially result from a dysfunction of the hypothalamus?
This condition is related to impaired water regulation.
Category: Basic Science Endocrinology
In response to a stressful event, which of the following hormones would be released from the hypothalamus to ultimately initiate the stress response?
Which hormone is primarily responsible for the milk production in lactating women?
This hormone is secreted by lactotroph cells in the anterior pituitary gland.
Which of the following is not a common cause of hyperprolactinemia?
This condition is related to the posterior pituitary gland.
What is the most common pituitary tumor in women?
This tumor is associated with the hormone responsible for milk production in lactating women.
What is the most effective treatment for prolactinomas?
This treatment option includes drugs such as cabergoline and bromocriptine.
In adults with excess growth hormone (GH) secretion, what is the resulting condition called?
This condition leads to enlarged hands, feet, and facial features.
Which hormone does the syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH) involve?
Which hormone is primarily responsible for the milk production in lactating women?
This hormone is secreted by lactotroph cells in the anterior pituitary gland.
Which of the following is not a common cause of hyperprolactinemia?
This condition is related to the posterior pituitary gland.
What is the most common pituitary tumor in women?
This tumor is associated with the hormone responsible for milk production in lactating women.
What is the most effective treatment for prolactinomas?
This treatment option includes drugs such as cabergoline and bromocriptine.
In adults with excess growth hormone (GH) secretion, what is the resulting condition called?
This condition leads to enlarged hands, feet, and facial features.
Which hormone does the syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH) involve?
Which part of the brain is responsible for regulating the release of hormones from the anterior pituitary gland?
This part of the brain is located just above the pituitary gland.
What is the primary function of antidiuretic hormone (ADH)?
This hormone helps to concentrate urine by increasing water reabsorption in the kidneys.
Which hormone is secreted by the hypothalamus to stimulate the release of growth hormone (GH) from the anterior pituitary gland?
This hormone specifically targets the release of GH.
What is the primary target organ of adrenocorticotropic hormone (ACTH)?
This organ is located on top of the kidneys.
Which hormone does the hypothalamus secrete to inhibit the release of prolactin from the anterior pituitary gland?
This hormone is also a neurotransmitter.
How does the hypothalamus primarily communicate with the posterior pituitary gland?
The communication between these two structures is facilitated by axons of neurosecretory cells.
Which hypothalamic nucleus is primarily responsible for synthesizing and releasing oxytocin?
This nucleus is involved in regulating various autonomic and neuroendocrine functions.
In the context of the hypothalamic-pituitary-adrenal (HPA) axis, what is the primary function of cortisol?
Cortisol acts as a negative feedback regulator in the HPA axis.
Which of the following conditions could potentially result from a dysfunction of the hypothalamus?
This condition is related to impaired water regulation.
In response to a stressful event, which of the following hormones would be released from the hypothalamus to ultimately initiate the stress response?
Which of the following pairs of hormones are synthesized by the hypothalamus and released by the posterior pituitary gland?
These hormones are synthesized by the hypothalamus and stored in the posterior pituitary gland until needed.
How is the release of growth hormone (GH) regulated by the hypothalamus?
The hypothalamus controls GH secretion by releasing stimulatory and inhibitory hormones.
Which of the following hypothalamic nuclei is primarily responsible for regulating appetite and body weight?
This nucleus contains neurons that produce appetite-stimulating and appetite-suppressing hormones.
What is the primary role of the hypothalamic-pituitary-gonadal (HPG) axis in males?
Which of the following scenarios best describes the hormone cascade involved in the hypothalamic-pituitary-adrenal (HPA) axis response to stress?
The hormone cascade involved in the HPA axis response to stress ultimately leads to cortisol release.
How does the hypothalamus contribute to maintaining circadian rhythm?
The hypothalamus contains a specific nucleus that acts as the body's internal clock.
Which of the following hormones is released in response to decreased blood pressure and acts on the kidneys to conserve water?
This hormone is synthesized by the hypothalamus and released by the posterior pituitary gland.
How does the hypothalamus primarily communicate with the anterior pituitary gland?
In patients with Sheehan's syndrome, which hormone levels would most likely be affected?
Sheehan's syndrome involves ischemic necrosis of the anterior pituitary.
Which hypothalamic hormone plays a significant role in modulating appetite and energy balance?
This hormone is primarily involved in appetite regulation and energy homeostasis.
What factor is responsible for the pulsatile release of growth hormone (GH) from the anterior pituitary gland?
The pulsatile release of GH is regulated by two hypothalamic hormones with opposing actions.
In a patient with a prolactinoma, what would be an expected effect on gonadotropin-releasing hormone (GnRH) secretion?
A patient presents with polyuria and polydipsia. Which condition would be associated with a decrease in vasopressin secretion?
This condition is characterized by a decrease in vasopressin secretion due to dysfunction in the hypothalamus or posterior pituitary.
Which of the following is a primary function of the hypothalamic-pituitary-adrenal (HPA) axis?
This axis is responsible for the secretion of cortisol, which plays a key role in the stress response.
In the presence of high cortisol levels, which hormone is expected to be suppressed?
High cortisol levels exert negative feedback on both the hypothalamus and anterior pituitary.
What is the primary hypothalamic hormone responsible for stimulating the release of growth hormone (GH) from the anterior pituitary gland?
The release of oxytocin from the posterior pituitary is primarily regulated by which mechanism?
Think about the mechanism that occurs during labor and breastfeeding.
Which of the following hormones is not secreted by the hypothalamus but has a major influence on its function?
This hormone is secreted by adipose tissue and regulates energy balance and appetite.
Which hormone released from the anterior pituitary has a pulsatile secretion pattern that is influenced by sleep?
This hormone is important for growth and development and is released primarily during deep, slow-wave sleep.
Which hypothalamic hormone is responsible for inhibiting the release of prolactin from the anterior pituitary?
This hormone is also known as prolactin-inhibiting factor (PIF).
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