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Which cells combine to generate a new diploid cell in the process of reproduction?
These cells contain half the normal number of chromosomes.
What are the male and female haploid gametes called?
These cells are produced by the male and female gonads.
Which gene on the Y chromosome plays a crucial role in the development of testes in a male fetus?
This gene is responsible for the presence and expression of Sertoli cells.
What is the function of the Sertoli cells in the development of the male reproductive system?
These cells are responsible for blocking the development of the primitive female reproductive tract.
What happens if the SRY-containing region on the Y chromosome is deleted or mutated in genetic males?
Which hormone is secreted by Leydig cells in the early testes?
These cells are involved in the development of the male reproductive system.
What structures do the Wolffian ducts develop into in the male reproductive system?
These structures are part of the male reproductive system.
In which week of fetal development do the paired indifferent gonads in a male fetus develop into testes?
The presence and expression of the SRY gene on the Y chromosome trigger this development.
Which cells remain quiescent until puberty and then become activated in males?
These cells are the initial stage of male gamete production.
How long does the cycle of spermatogenesis take in humans?
The length of this cycle is species dependent.
What is the condition called when a genetic male has a defect that decreases tissue-specific androgen sensitivity?
This condition results in the regression of female Müllerian ducts but a failure to respond in androgen-sensitive tissues.
Which hormone is believed to act on the gubernaculum during testes migration in the developing human male fetus?
This hormone is produced by the Sertoli cells.
What is the term for the condition in which the testes fail to descend and remain hidden within the body?
This condition is associated with infertility.
What is the role of Sertoli cells in the final development process of spermatocytes?
These cells have specialized connections called ectoplasmic specializations with spermatocytes.
In which fluid space are primary spermatocytes formed in the male reproductive system?
This fluid space is located around the seminiferous tubules.
What is the name of the specialized connections between secondary spermatocytes and Sertoli cells?
These connections play a role in the attachment of spermatocytes to Sertoli cells.
Which hormone, produced by interstitial Leydig cells, stimulates the development of the Wolffian ducts and the male external genitalia?
This hormone is responsible for further development along the male line.
Which arteries provide arterial blood to the surface of each testis?
These arteries supply blood to the testis surface from different sources.
Which part of the testis provides a heat exchange system due to the close proximity of arterial and venous systems?
This system helps in keeping the temperature of the incoming blood lower and the departing blood higher.
What does the barrier formed by multiple tight and gap junctions encircling Sertoli cells prevent?
This barrier develops only at puberty when spermatogenesis begins.
What is the primary hormone that Sertoli cells synthesize receptors for?
This hormone comes from the anterior pituitary.
What is the primary function of Leydig cells in the testes?
These cells are endocrine cells located within the interstitial fluid compartment.
Which hormone do Sertoli cells secrete in addition to producing many other substances?
This hormone is produced by endocrine cells within the seminiferous tubules.
Which glands synthesize androgens to a limited extent, and their production is particularly relevant in females?
These glands are not part of the reproductive system but do produce hormones that affect it.
What is the name given to the bundle of arteries, veins, and reproductive tract (vas deferens) from each testis passing through the inguinal canal?
This structure connects the testes to the rest of the reproductive system.
Which cells in the testes synthesize androgens?
These cells are found in small groups within the interstitial fluid present between the seminiferous tubules.
What enzyme converts testosterone to dihydrotestosterone (DHT)?
This enzyme is present in many androgen-responsive tissues, including the prostate, skin, and sebaceous glands.
What protein does testosterone bind to in the bloodstream?
This plasma protein also binds other sex hormones such as oestrogens and progestogens.
What binding protein does testosterone bind to in the seminiferous fluid?
This binding protein is more selective compared to the one found in the bloodstream.
Where are androgen receptors primarily located within target cells?
Which hormone acts as a precursor to all other steroids in the synthesis pathway of androgens?
This hormone is synthesized from cholesterol early on in the pathway.
Which enzyme converts testosterone to the potent 17β-oestradiol?
This enzyme is found in some tissues and converts testosterone to a hormone that is particularly important in females but also has effects in males.
What is the main testicular androgen produced from the weak dehydroepiandrosterone (DHEA) and androstenedione?
This hormone is a potent androgen in its own right and can be converted to an even more powerful androgen by the enzyme 5α-reductase.
Which anterior pituitary hormone is crucial for the initiation of spermatogenesis?
This hormone binds to its receptors in the Sertoli cells and induces activities necessary for the spermatogenic process.
Which enzyme is responsible for the aromatisation of testosterone to oestrogens in Sertoli cells?
This enzyme converts testosterone to oestrogens in Sertoli cells.
What is the main function of the accessory sex glands in males?
These glands contribute to the seminal fluid by providing nutrients and fluid volume.
Which hormone stimulates the synthesis of androgens by the interstitial Leydig cells?
This hormone is released by the anterior pituitary and is involved in stimulating androgen production.
What is the main source of fructose and sorbitol in human semen?
What is the primary role of androgens during puberty?
This hormone is responsible for the development of specific characteristics in males during adolescence.
Which hormone is produced by the Sertoli cells following FSH stimulation?
This hormone is produced by Sertoli cells and is involved in the regulation of the hypothalamo-adenohypophysial axis.
What happens to spermatozoa once they reach the epididymis?
In this part of the male reproductive system, spermatozoa undergo a process involving water reabsorption.
Which accessory sex gland contributes the largest volume of fluid to human semen?
This gland contributes about 60% of the total volume of human semen.
What is the role of androgens in protein metabolism?
Androgens are considered anabolic steroids and play a role in a specific type of metabolism.
Which hormone stimulates the production of erythropoietin, leading to an increase in erythrocyte proliferation?
This hormone is an androgen that plays a role in the production of a specific hormone that influences erythrocyte proliferation.
Which cells synthesize inhibin in response to FSH stimulation in males?
These cells are found in the male reproductive system and are involved in the synthesis of inhibin in response to FSH.
What is the primary endocrine influence on Leydig cells for the production of androgens?
This hormone is released from the anterior pituitary gland and influences Leydig cells in the testes to produce androgens.
What is the effect of androgens on sebaceous secretion?
Androgens have an effect on sebaceous glands and can lead to a common skin problem in adolescents.
What are the glycoproteins that bind to activin molecules and block their activity?
These glycoproteins are produced by gonadotrophs and folliculostellate cells and have a blocking effect on activin molecules.
What is the primary hormone responsible for controlling Sertoli cell function?
This hormone is produced by the anterior pituitary gland and acts on the Sertoli cells in the testes.
Which hormone is responsible for the pubertal growth spurt in males?
This growth spurt is due to the combined action of an androgen and another hormone that influences growth.
Which factors play a significant role in determining the successful development of penile erection?
These factors are related to the senses and play a key role in penile erection.
What is the neurotransmitter responsible for stimulating the synthesis of nitric oxide during penile erection?
This neurotransmitter is released by parasympathetic nerve fibers and is involved in the vasodilation process.
Which drug is commonly used to treat erectile dysfunction by inhibiting the enzyme responsible for degrading cGMP?
This drug is also known as Viagra and is a popular treatment for erectile dysfunction.
What is the commonest cause of primary testicular failure?
This syndrome is characterized by an extra chromosome (47 XXY) and is associated with small testes, azoospermia, and gynecomastia.
Which part of the penis does not contribute to the development of an erection but provides blood to the glans and the skin of the penis?
This artery runs along the length of the penis and is separate from the main structure responsible for an erection.
What prevents the collapse of the central urethra during penile erection?
This structure is a venous sinusoidal space that surrounds the urethra and has a spongy appearance.
What is the primary reason for impotence in males?
Impotence is a result of a failure to achieve a specific penile state.
During which phase of sleep do nocturnal erections occur?
This phase of sleep is associated with dreaming and is characterized by rapid eye movements.
What condition is caused by a defective testosterone receptor and results in a phenotypic normal female with testes?
This condition is caused by a genetic defect in the X-chromosome and affects the way the body responds to testosterone.
Which condition is characterized by the swelling or inflammation of the epididymis and may occur as a result of bacterial or chlamydial infection?
This condition typically affects males between the ages of 19 and 35 and can cause fever, tenderness, and pain in the scrotum.
What is a hydrocoele and what causes it?
This condition causes a soft, non-tender and cystic swelling in the scrotum and the testis cannot be palpated due to the fluid collection.
What is the most common age range for the occurrence of testicular tumors?
These tumors often originate from germ cells and are more prevalent in younger adult males.
What is a varicocoele and why is it more common on the left side?
This condition can cause a 'bag of worms' feeling and is related to the pressure in the renal veins.
Which condition requires emergency surgery to protect the vascular supply to the testicle?
This condition often presents with acute pain and can lead to testicular infarction if not treated promptly.
What is the classic testicular histopathology observed in adult men with Klinefelter's syndrome?
This histopathological finding is specific to a chromosomal disorder affecting males.
In which condition does the patient experience primary amenorrhea and has a short blind-ending vagina without a uterus?
What are the two main functions of the female ovaries?
These two functions are essential for the procreation of the species.
What is the difference between oestrous cycles and menstrual cycles?
One type of cycle is found in rodents, while the other is found in primates.
What is the name of the axis that links ovarian and endometrial events through endocrine regulation?
This axis involves the hypothalamus, the anterior pituitary, and the ovaries.
How many primary oocytes are formed in the female fetus during the initial mitotic divisions of germ cells?
Which of the following effects is associated with oestrogens in the cardiovascular system?
Oestrogens have a beneficial effect on the cardiovascular system by influencing lipoprotein cholesterol.
How do oestrogens affect protein synthesis?
Oestrogens have an effect on protein synthesis, especially during puberty.
What is the main effect of oestrogens on the endometrium during the proliferative phase of the endometrial cycle?
Oestrogens have an effect on the endometrium during the proliferative phase of the endometrial cycle.
How do oestrogens affect cervical secretion during the follicular phase of the ovarian cycle?
Oestrogens have an effect on cervical secretion during the follicular phase of the ovarian cycle.
Which of the following is a consequence of excessively raised circulating androgens or oestrogens during puberty?
Excessive gonadal steroids during puberty affect skeletal maturity and final height.
How do oestrogens affect renal sodium reabsorption?
Oestrogens have an effect on renal sodium reabsorption.
Which of the following effects do oestrogens have on the gastrointestinal system?
Oestrogens affect calcium absorption in the gastrointestinal system.
Which of the following is a central effect of oestrogens on behavior?
Oestrogens have central effects on behavior.
Which hormone plays a key role in stimulating ductile growth in breast tissue development?
Breast tissue development is influenced by hormones, with one playing a key role in ductile growth.
What is the primary role of high-density lipoproteins (HDL) in relation to oestrogens?
HDL has a specific role in cholesterol redistribution under the influence of oestrogens.
Which of the following is a consequence of decreased levels of circulating oestrogen after menopause?
Menopause and decreased oestrogen levels have an impact on coronary artery disease risk.
How do oestrogens affect bone mineralisation?
Oestrogens have an effect on bone mineralisation through their actions on osteoblasts and osteoclasts.
In which phase of the ovarian cycle is progesterone mainly synthesized?
Progesterone synthesis is linked to a specific phase of the ovarian cycle.
What is the main role of progesterone in the endometrium?
Progesterone has a specific function in the endometrium during the secretory phase.
Which of the following is NOT a naturally occurring progestogen?
One of the options is an estrogen, not a progestogen.
Which protein transports most of the progesterone in the blood?
The majority of progesterone is bound to a specific plasma protein.
What effect does progesterone have on cervical secretions after ovulation?
Progesterone has an effect on cervical secretions after ovulation.
How does progesterone affect sodium reabsorption in the distal nephron?
Progesterone has an effect on aldosterone-mediated sodium reabsorption.
Which of the following hormones does inhibin primarily inhibit?
Inhibin has a specific effect on one of the hormones involved in the ovarian cycle.
In which cells are inhibins synthesized in the ovaries?
Inhibin synthesis occurs in a specific type of ovarian cells.
What is the main source of progesterone during the luteal phase of the ovarian cycle?
Progesterone has a primary source during the luteal phase of the ovarian cycle.
How does progesterone affect basal body temperature after ovulation?
Progesterone has an effect on basal body temperature after ovulation.
What is the main role of progesterone in the endometrial cycle?
Progesterone has a primary function during the endometrial cycle.
Which of the following is NOT a naturally occurring progestogen?
One of the options is an estrogen, not a progestogen.
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