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Reading & Community

Endocrine Journal Club

Physician-authored reviews of the most-discussed endocrinology papers — design, statistical caveats, and what actually changes at the bedside.

3 reviews published

Journal club

GRADE Study – Journal Club

The Glycemia Reduction Approaches in Type 2 Diabetes – A comparative effectiveness (GRADE) Study[1] was a study to assess the effectiveness of various add-on therapies to metformin in…

Journal club

FIDELIO-DKD (Journal Club)

Finerenone in Subjects with Type 2 Diabetes Mellitus and Diabetic Kidney Disease. The FIDELIO-DKD clinical trial is summarized in this simple infographic. Review study protocolRead Study Publication Rationale…

Journal club

SOLOIST WHF

Effect of Sotagliflozin on Cardiovascular Events in Patients with Type 2 Diabetes Post Worsening Heart Failure. Review study protocolRead Study Publication Rationale and Clinical Equipoise Sotagliflozin inhibits both…

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How we read a paper

Every journal-club post is structured around the same five checks:

  1. Study design (RCT? observational? crossover?)
  2. PICO / population selection and enrolment
  3. Primary and secondary endpoints
  4. Effect size, confidence intervals, and NNT
  5. Where it sits versus current guidelines

Endocrine Journal Club is a monthly discussion of essential studies in endocrinology. Although the emphasis is placed on recent publications, we will occasionally review landmark studies of yesteryear. Each study is summarized via a comprehensive visual abstract with an additional brief blog-style post. Kindly register (sign in via your social media account to make it a seamless process) to comment on the post. 

Critical appraisal 

“The process of carefully and systematically examining research to judge its trustworthiness, and its value and relevance in a particular context” 

Of course, no trial is perfect. We can always find points to criticize in a trial, but this does not necessarily mean that the results cannot be trusted or applied in practice. However, sometimes authors over-interpret their results and ignore the weaknesses of their trial. Critical appraisal allows us to assess in a systematic way how strong or weak a paper is in answering a clinically relevant question, and so decide whether (and how) the results and conclusions can be applied to clinical practice. It is usually applied to a paper that has already been published rather than one in preparation. 

Clinical Trial Commentary

Join our discord channel and get notified during our next scheduled journal club. Meet like-minded people interested in hormone science. Review our recent clinical trial commentary held before a formal journal club meeting.

Endocrine Journal Club (Archives)

StudyReview
EMPEROR-PreservedEmperor Preserved
SOLOIST WHFsoloist-whf
FIDELIO-DKDFIDELIO DKD
GRADE StudyGRADE Study
FRAME StudyFRAME Study

Clinical Trials!

Start this introductory course to clinical trials and the critical appraisal of research