Mechanism of Action Series : This series of articles in clinical endocrinology is designed for endocrinology fellows interested in gaining a better understanding of endocrine pathophysiology. These carefully selected concise articles are part of our “Understanding endocrine pathophysiology series”

Why this series in endocrine pathophysiology?
- We have sought to present endocrine pathophysiology in a manner that emphasizes more practical concepts compared to traditional textbooks on the topic. This text facilitates an integrated approach to learning endocrine pathophysiology through an appreciation of the mechanism of action of medical therapies. Relevant endocrine physiology is presented before a detailed description of the mechanism of action of selected medical interventions. Several illustrations and well-annotated line diagrams are used to enhance an efficient review of basic and advanced endocrine pathophysiology concepts. Also, clinical pharmacology pearls (side effects and therapeutic monitoring guidelines) are emphasized where applicable.
- Clinical practice guidelines change over time as our knowledge of disease states evolves. Endocrinology is a complex subdiscipline of internal medicine characterized by a rapid turnover of knowledge. As a result, we have avoided emphasizing guideline-defined treatment protocols in favor of the pathophysiologic basis of endocrine therapies. This series of articles is by no means exhaustive concerning endocrine pathophysiology. We, however, hope that a discussion of various endocrine therapies will facilitate a better appreciation of complex concepts in endocrine physiology in a more clinically relevant manner.
- Also, endocrinology fellows and practising physicians should be familiar with landmark clinical trials in the field. We have made a concerted effort to highlight practice-changing clinical trials where relevant. We hope this will enrich the training of not only endocrinology fellows but also internal medicine residents, medical students, and other allied health professionals such as pharmacists, nurse practitioners, and physician assistants.
- We welcome feedback from our web audience regarding the limitations of this series and look forward to incorporating valuable suggestions in future editions. The MyEndoConsult team went through painstaking efforts to create this series of articles and welcome suggestions for improving it.
Mechanism of Action of drugs for Cushing’s Syndrome
Bromocriptine in Cushings Disease
Bromocriptine in Cushings Disease The mechanism of action of bromocriptine and its clinical application in the management of Cushing’s disease will be reviewed. Physiology The
Retinoic Acid Mechanism of Action
Retinoic Acid Mechanism of Action The mechanism of action of retinoic acid and its clinical application in the management of Cushing’s disease will be reviewed.
Mechanism of Action of Pasireotide
Mechanism of Action of Pasireotide The mechanism of action of pasireotide and its clinical application in the management of Cushing’s disease will be reviewed. Endocrine
Mechanism of action of steroidogenesis inhibitors
Mechanism of action of steroidogenesis inhibitors The mechanism of action of various steroidogenesis inhibitors and their clinical application in managing Cushing’s disease will be reviewed.
Mifepristone Mechanism of Action
Mifepristone Mechanism of Action The mechanism of action of mifepristone and its clinical application in the management of Cushing’s disease will be reviewed. Physiology Glucocorticoid
Mechanism of Action of drugs for Acromegaly
Cabergoline for Acromegaly
Cabergoline for Acromegaly The mechanism of action of cabergoline and its clinical application in the management of acromegaly will be reviewed. Physiology Growth hormone physiology and
Pegvisomant for acromegaly
Pegvisomant for acromegaly The mechanism of action of pegvisomant and its clinical application in the management of acromegaly will be reviewed. Physiology Growth hormone and
Somatostatin Analogs and Acromegaly
Somatostatin Analogs and Acromegaly The mechanism of action of somatostatin analog therapy and its clinical application in managing acromegaly will be reviewed. Physiology The role
Mechanism of action of drugs for prolactinoma
How does bromocriptine work in prolactinoma
How does bromocriptine work in prolactinoma The mechanism of action of bromocriptine and cabergoline and their clinical application in the management of prolactinomas will be reviewed.
Mechanism of action of temozolamide
Mechanism of action of temozolamide The mechanism of action of temozolomide and its clinical application in the management of prolactinomas will be reviewed. Physiology Cellular protective
Mechanism of action of drugs for Growth Hormone Deficiency
Mechanism of Action of Growth Hormone
Mechanism of Action of Growth Hormone The mechanism of action of growth hormone and its clinical application in the management of adult growth hormone deficiency
Mechanism of action of drugs for Diabetes Insipidus


Desmopressin mechanism of action diabetes insipidus
Desmopressin mechanism of action diabetes insipidus The mechanism of action of desmopressin and its clinical application in the management of central diabetes insipidus will be

Board Certified in Diabetes, Endocrinology and Metabolism. Board Certified in Internal Medicine.