Diabetes and Endocrinology Trials

Important Trials in Diabetes and Endocrinology 2023
4 Topics
The ONWARDS3 Clinical Trial
Is Testosterone Therapy Safe for the Heart? Insights from the TRAVERSE Study
Retatrutide Clinical Trial
Orforglipron vs. Type 2 Diabetes: A Breakthrough in Oral Treatment?
Important Trials in Diabetes and Endocrinology 2021
14 Topics
Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass.
SURPASS-2: A Study of Tirzepatide Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes
STEP 1 : Semaglutide Treatment Effect in People with Obesity
SOLOIST-WHF: Effect of Sotagliflozin on Cardiovascular Events in Patients with Type 2 Diabetes Post Worsening Heart Failure.
SCORED : Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients with Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk
A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis
MOBILE : Continuous Glucose MOnitoring in T2D Basal InsuLin UsErs.
Association of metabolic-bariatric surgery with long-term survival in adults with and without diabetes
FIDELIO-DKD: Finerenone in Subjects with Type 2 Diabetes Mellitus and Diabetic Kidney Disease
EMPEROR-Preserved: EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction.
COMPASS: Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia
AMPLITUDE-O: Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes.
AfterDmab: Zoledronic Acid to Maintain Bone Mass After Denosumab Discontinuation.
ACTIVE : Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial
Reproductive Endocrinology
8 Topics
WHI E + P
AMIGOS : Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility
HERS Study
KEEPS Study : Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a randomized trial
PCOS (LETROZOLE STUDY)
FET
ELITE – The Early versus Late Intervention Trial with Estradiol
PCOS
Diabetes Mellitus
24 Topics
ADVANCE : Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
ACCORD : Effects of intensive glucose lowering in type 2 diabetes
CANVAS : Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes.
D2d TRIAL: Vitamin D Supplementation and Prevention of Type 2 Diabetes.
DCCT : The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.
DPP: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. The Diabetes Prevention Program
HAPO: Hyperglycemia and Adverse Pregnancy Outcomes. The HAPO Study Cooperative Research Group
LEADER : Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus: A Randomized Trial
Look AHEAD – Look Action for HEAlth in Diabetes.
NICE-SUGAR : Intensive versus conventional glucose control in critically ill patients
CREDENCE
DAPA-HF: Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction
DECLARE-TIMI 58
iDCL: The international Diabetes Closed Loop Trial: The Clinical Acceptance of the Artificial Pancreas
Look AHEAD: Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. Look Action for HEAlth in Diabetes.
RENAAL: Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan
UKPDS 33
U500-R (“HOOD study”)
PROactive
1 of 2
Calcium and Bone Metabolism
7 Topics
Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial
FIT : Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group
PTH(1-34) : Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis
FRAME : Romosozumab Treatment in Postmenopausal Women with Osteoporosis
FREEDOM : Denosumab for prevention of fractures in postmenopausal women with osteoporosis
HORIZON : Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis
Zoledronic Acid Recurrent Fracture Trial
Pituitary Disorders
2 Topics
PASIREOTIDE B2305 STUDY GROUP : A 12-month phase 3 study of pasireotide in Cushing’s disease
COPEPTIN – A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus
Lipidology and Obesity
13 Topics
RECORD: Rosiglitazone Evaluated for Cardiovascular Outcomes in oRal agent combination therapy for type 2 Diabetes mellitus
4S : The Scandinavian Simvastatin Survival Study
JUPITER – Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
IMPROVE-IT : Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes
HPS3/TIMI55 : Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
HOPE-3 Trial : Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease
ASCEND : Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus
CONQUER
CAMELLIA-TIMI 61 : Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients
COR1
STAMPEDE : Bariatric surgery versus intensive medical therapy in obese patients with diabetes
ORIGIN N-3 Fatty Acid
ODYSSEY OUTCOMES : Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome
Hypertension and Adrenal Disorders
2 Topics
SPRINT
SPYRAL HTN-ON MED
Thyroid Diseases
7 Topics
SCH – Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy.
DECISION STUDY
OPTIC – Treatment of Graves’ Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in a Clinical Study
RAI
TABLET – Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception. Thyroid AntiBodies and LEvoThyroxine study
WDTC
ZETA Study
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Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial

Diabetes and Endocrinology Trials Calcium and Bone Metabolism Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial

Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial

 When choosing initial or sequential therapy in the management of postmenopausal osteoporosis, the results of this study should be considered.

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Reference

Leder BZ, Tsai JN, Uihlein AV, Wallace PM, Lee H, Neer RM, Burnett-Bowie SA. Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial. Lancet. 2015 Sep 19;386(9999):1147-55.

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