TABLET – Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception. Thyroid AntiBodies and LEvoThyroxine study

TABLET – Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception. Thyroid AntiBodies and LEvoThyroxine study

• In contrast to the results from previous small and inadequately powered studies which suggested some benefits of preconception LT4 in increasing live birth rates, TABLET answered some important questions about pregnancy outcomes in this patient population.
• For TPOAb POSITIVE, euthyroid women, LT4 does NOT have any significant effect on pregnancy or neonatal outcomes.

Infographic

Reference

Dhillon-Smith RK, Middleton LJ, Sunner KK, Cheed V, Baker K, Farrell-Carver S, Bender-Atik R, Agrawal R, Bhatia K, Edi-Osagie E, Ghobara T, Gupta P, Jurkovic D, Khalaf Y, MacLean M, McCabe C, Mulbagal K, Nunes N, Overton C, Quenby S, Rai R, Raine-Fenning N, Robinson L, Ross J, Sizer A, Small R, Tan A, Underwood M, Kilby MD, Boelaert K, Daniels J, Thangaratinam S, Chan SY, Coomarasamy A. Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception. N Engl J Med. 2019 Apr 4;380(14):1316-1325.

>