The ONWARDS3 Clinical Trial

Is Testosterone Therapy Safe for the Heart? Insights from the TRAVERSE Study

Retatrutide Clinical Trial

Orforglipron vs. Type 2 Diabetes: A Breakthrough in Oral Treatment?

Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass.

SURPASS-2: A Study of Tirzepatide Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes

STEP 1 : Semaglutide Treatment Effect in People with Obesity

SOLOIST-WHF: Effect of Sotagliflozin on Cardiovascular Events in Patients with Type 2 Diabetes Post Worsening Heart Failure.

SCORED : Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients with Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

MOBILE : Continuous Glucose MOnitoring in T2D Basal InsuLin UsErs.

Association of metabolic-bariatric surgery with long-term survival in adults with and without diabetes

FIDELIO-DKD: Finerenone in Subjects with Type 2 Diabetes Mellitus and Diabetic Kidney Disease

EMPEROR-Preserved: EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction.

COMPASS: Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia

AMPLITUDE-O: Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes.

AfterDmab: Zoledronic Acid to Maintain Bone Mass After Denosumab Discontinuation.

ACTIVE : Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial

WHI E + P

AMIGOS : Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility

HERS Study

KEEPS Study : Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a randomized trial

PCOS (LETROZOLE STUDY)

FET

ELITE – The Early versus Late Intervention Trial with Estradiol

PCOS

ADVANCE : Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes

ACCORD : Effects of intensive glucose lowering in type 2 diabetes

CANVAS : Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes.

D2d TRIAL: Vitamin D Supplementation and Prevention of Type 2 Diabetes.

DCCT : The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.

DPP: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. The Diabetes Prevention Program

HAPO: Hyperglycemia and Adverse Pregnancy Outcomes. The HAPO Study Cooperative Research Group

LEADER : Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus: A Randomized Trial

Look AHEAD – Look Action for HEAlth in Diabetes.

NICE-SUGAR : Intensive versus conventional glucose control in critically ill patients

CREDENCE

DAPA-HF: Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction

DECLARE-TIMI 58

iDCL: The international Diabetes Closed Loop Trial: The Clinical Acceptance of the Artificial Pancreas

Look AHEAD: Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. Look Action for HEAlth in Diabetes.

RENAAL: Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan

UKPDS 33

U500-R (“HOOD study”)

PROactive

Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial

FIT : Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group

PTH(1-34) : Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis

FRAME : Romosozumab Treatment in Postmenopausal Women with Osteoporosis

FREEDOM : Denosumab for prevention of fractures in postmenopausal women with osteoporosis

HORIZON : Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis

Zoledronic Acid Recurrent Fracture Trial

RECORD: Rosiglitazone Evaluated for Cardiovascular Outcomes in oRal agent combination therapy for type 2 Diabetes mellitus

4S : The Scandinavian Simvastatin Survival Study

JUPITER – Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein

IMPROVE-IT : Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

HPS3/TIMI55 : Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

HOPE-3 Trial : Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease

ASCEND : Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus

CONQUER

CAMELLIA-TIMI 61 : Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients

COR1

STAMPEDE : Bariatric surgery versus intensive medical therapy in obese patients with diabetes

ORIGIN N-3 Fatty Acid

ODYSSEY OUTCOMES : Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

SPRINT

SPYRAL HTN-ON MED

SCH – Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy.

DECISION STUDY

OPTIC – Treatment of Graves’ Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in a Clinical Study

RAI

TABLET – Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception. Thyroid AntiBodies and LEvoThyroxine study

WDTC

ZETA Study