4S : The Scandinavian Simvastatin Survival Study

The association of hyperlipidemia was previously reported in the Framingham Study (published in 1961). In patients with known coronary artery disease, does simvastatin therapy reduce all-cause mortality?

For adults aged 40 to 75 years with diabetes mellitus and an LDL-cholesterol level of 70mg/dl or higher, starting moderate-intensity statin without the need to calculate 10-year ASCVD risk is recommended (2018 ACC/AHA lipid guidelines)

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Reference

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994 Nov 19;344(8934):1383-9.