ADVANCE: Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.
• An A1C goal of <6.5% results in a significant reduction in the risk of nephropathy, based on the ADVANCE study.
• The American Association of Clinical Endocrinologists recommends an A1C goal of ≤6.5% for most patients if it can be achieved safely without the risk of hypoglycemia. (AACE 2018)
• An A1C goal of ≤6.5 is recommended in patients with recently diagnosed T2DM and no clinically significant CVD. (AACE 2018)
ADVANCE Collaborative Group, Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, Marre M, Cooper M, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Liu L, Mancia G, Mogensen CE, Pan C, Poulter N, Rodgers A, Williams B, Bompoint S, de Galan BE, Joshi R, Travert F. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008 Jun 12;358(24):2560-72.