AMIGOS : Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility
• Letrozole resulted in a lower frequency of both live birth and multiple gestations when compared to gonadotropin therapy alone. Letrozole however did not differ significantly from clomiphene with
regards to live birth and multiple gestation rates.
• The results of this study differ significantly from that of the PPCOSII study which recruited
Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Ager J, Huang H, Hansen KR, Baker V, Usadi R, Seungdamrong A, Bates GW, Rosen RM, Haisenleder D, Krawetz SA, Barnhart K, Trussell JC, Ohl D, Jin Y, Santoro N, Eisenberg E, Zhang H; NICHD Reproductive Medicine Network. Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. N Engl J Med. 2015 Sep 24;373(13):1230-40.