Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass.
Rationale : Bariatric surgery, particularly Roux-en-Y gastric bypass (RYGB), is associated
with an increased risk of osteoporotic fractures. It is unknown whether RYGB or sleeve
gastrectomy (SG) have different effects on bone health.
Participants : Age ≥18 years, current BMI ≥ 33.0kg/m2 with previously verified BMI ≥ 35.0kg/m²
Type 2 diabetes (Hemoglobin A1c [HbA1c] ≥ 6.5% or on anti-diabetic medications
Outcome : Changes in areal bone mineral density (aBMD) and bone turnover
markers. *Total hip aBMD reported in this abstract.
Mean between-group difference (aBMD), between Roux-en-Y Gastric Bypass and Sleeve Gastrectomy of -3.0% ; 95% CI, -5.0 to -0.9; P value = 0.005
Practice Changing Pearls: Areal BMD in the femoral neck, total hip, and lumbar spine decreased significantly more after gastric bypass than after sleeve gastrectomy during follow-up. By contrast, the reduction in total body aBMD did not differ between RYGB and SG.
Dag Hofsø, Thor Olav Widerøe Hillestad, Erling Halvorsen, Farhat Fatima, Line Kristin Johnson, Morten Lindberg, Marius Svanevik, Rune Sandbu, Jøran Hjelmesæth, Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial (Oseberg), The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 2, February 2021, Pages 501–511