Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass.

Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass.

Rationale : Bariatric surgery, particularly Roux-en-Y gastric bypass (RYGB), is associated
with an increased risk of osteoporotic fractures. It is unknown whether RYGB or sleeve
gastrectomy (SG) have different effects on bone health.

Abstract

Participants : Age ≥18 years, current BMI ≥ 33.0kg/m2 with previously verified BMI ≥ 35.0kg/m²
Type 2 diabetes (Hemoglobin A1c [HbA1c] ≥ 6.5% or on anti-diabetic medications

Outcome : Changes in areal bone mineral density (aBMD) and bone turnover
markers. *Total hip aBMD reported in this abstract.

Mean between-group difference (aBMD), between Roux-en-Y Gastric Bypass and Sleeve Gastrectomy of -3.0% ; 95% CI, -5.0 to -0.9; P value = 0.005

Practice Changing Pearls: Areal BMD in the femoral neck, total hip, and lumbar spine decreased significantly more after gastric bypass than after sleeve gastrectomy during follow-up. By contrast, the reduction in total body aBMD did not differ between RYGB and SG.

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Reference

Dag Hofsø, Thor Olav Widerøe Hillestad, Erling Halvorsen, Farhat Fatima, Line Kristin Johnson, Morten Lindberg, Marius Svanevik, Rune Sandbu, Jøran Hjelmesæth, Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial (Oseberg), The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 2, February 2021, Pages 501–511

About the author 

MyEndoConsult

The MyEndoconsult Team. A group of physicians dedicated to endocrinology and internal medicine education.

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