ELITE – The Early versus Late Intervention Trial with Estradiol
• Unlike the KEEPS study which showed no beneficial effect of HRT in early postmenopausal women, the ELITE trial showed a beneficial effect of HRT in this group – further affirming the “hormone
• Menopausal hormone therapy should not be initiated in postmenopausal women who are either >60years or > 10years since the diagnosis of menopause (Endocrine Society).
Harman SM, Black DM, Naftolin F, Brinton EA, Budoff MJ, Cedars MI, Hopkins PN, Lobo RA, Manson JE, Merriam GR, Miller VM, Neal-Perry G, Santoro N, Taylor HS, Vittinghoff E, Yan M, Hodis HN. Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a randomized trial. Ann Intern Med. 2014 Aug 19;161(4):249-60.