KEEPS Study : Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a randomized trial
• In contrast to observational data, early initiation of menopausal hormone therapy (MHT) did not affect the progression of atherosclerosis.
• A major limitation of this study is its lack of generalizability (white women and low CVD risk factors at baseline)
• In recently menopausal women, a short course of MHT does not increase or decrease atherosclerosis progression. (Menopause Society)
Harman SM, Black DM, Naftolin F, Brinton EA, Budoff MJ, Cedars MI, Hopkins PN, Lobo RA, Manson JE, Merriam GR, Miller VM, Neal-Perry G, Santoro N, Taylor HS, Vittinghoff E, Yan M, Hodis HN. Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a randomized trial. Ann Intern Med. 2014 Aug 19;161(4):249-60.