U500-R (“HOOD study”)

TWO TREATMENT APPROACHES FOR HUMAN REGULAR U-500 INSULIN IN PATIENTS WITH TYPE 2 DIABETES NOT ACHIEVING ADEQUATE GLYCEMIC CONTROL ON HIGH-DOSE U-100 INSULIN THERAPY WITH OR WITHOUT ORAL AGENTS: A RANDOMIZED, TITRATION-TO-TARGET CLINICAL TRIAL

• The titration algorithm for U-500R used in this trial is based on plasma equivalent glucose doses (Maximum increase per visit was 30%/day; maximum decrease per visit was 20%/day)

• U500-R using an algorithm-based approach improves glycemic control and is more convenient (less daily injections compared to conventional intensive insulin therapy) for patients on high-dose U-100 insulin.

Infographic

Reference

Hood RC, Arakaki RF, Wysham C, Li YG, Settles JA, Jackson JA. TWO TREATMENT APPROACHES FOR HUMAN REGULAR U-500 INSULIN IN PATIENTS WITH TYPE 2 DIABETES NOT ACHIEVING ADEQUATE GLYCEMIC CONTROL ON HIGH-DOSE U-100 INSULIN THERAPY WITH OR WITHOUT ORAL AGENTS: A RANDOMIZED, TITRATION-TO-TARGET CLINICAL TRIAL. Endocr Pract. 2015 Jul;21(7):782-93. doi: 10.4158/EP15612.OR. Epub 2015 Mar 26. Erratum in: Endocr Pract. 2016 Jul;22(7):905.

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