ACCORD : Effects of intensive glucose lowering in type 2 diabetes
Intensive glycemic control increases the risk of hypoglycemia compared to current conventional glycemic control.
• Intensive glycemic control increases the annual rate of all-cause mortality (Number needed to harm of 370) when compared to conventional therapy.
• In T2DM patients with CVD risk factors SBP<120mmHg was no better than <140mmHg (ACCORD-BP)
• Addition of fibrates to statins does not reduce CVD endpoints (ACCORD-lipid)
Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC, Miller ME, Byington RP, Goff DC Jr, Bigger JT, Buse JB, Cushman WC, Genuth S, Ismail-Beigi F, Grimm RH Jr, Probstfield JL, Simons-Morton DG, Friedewald WT. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008 Jun 12;358(24):2545-59.