November 4, 2021

Diabetes and Endocrinology Trials

A collection of visual abstracts of landmark clinical trials in diabetes care and endocrinology.

Course Content

Important Trials in Diabetes and Endocrinology 2023 4 Topics

Lesson Content

0% Complete 0/4 Steps

The ONWARDS3 Clinical Trial

Is Testosterone Therapy Safe for the Heart? Insights from the TRAVERSE Study

Retatrutide Clinical Trial

Orforglipron vs. Type 2 Diabetes: A Breakthrough in Oral Treatment?

Important Trials in Diabetes and Endocrinology 2021 14 Topics

Lesson Content

0% Complete 0/14 Steps

Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass.

SURPASS-2: A Study of Tirzepatide Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes

STEP 1 : Semaglutide Treatment Effect in People with Obesity

SOLOIST-WHF: Effect of Sotagliflozin on Cardiovascular Events in Patients with Type 2 Diabetes Post Worsening Heart Failure.

SCORED : Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients with Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

MOBILE : Continuous Glucose MOnitoring in T2D Basal InsuLin UsErs.

Association of metabolic-bariatric surgery with long-term survival in adults with and without diabetes

FIDELIO-DKD: Finerenone in Subjects with Type 2 Diabetes Mellitus and Diabetic Kidney Disease

EMPEROR-Preserved: EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction.

COMPASS: Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia

AMPLITUDE-O: Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes.

AfterDmab: Zoledronic Acid to Maintain Bone Mass After Denosumab Discontinuation.

ACTIVE : Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial

Reproductive Endocrinology 8 Topics

Lesson Content

0% Complete 0/8 Steps

AMIGOS : Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility

KEEPS Study : Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a randomized trial

PCOS (LETROZOLE STUDY)

ELITE – The Early versus Late Intervention Trial with Estradiol

Diabetes Mellitus 24 Topics

Lesson Content

0% Complete 0/24 Steps

EMPA-REG OUTCOME : Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

DAPS Study : Denosumab Adherence Preference Satisfaction Study

2 of 2

Calcium and Bone Metabolism 7 Topics

Lesson Content

0% Complete 0/7 Steps

Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial

FIT : Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group

PTH(1-34) : Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis

FRAME : Romosozumab Treatment in Postmenopausal Women with Osteoporosis

FREEDOM : Denosumab for prevention of fractures in postmenopausal women with osteoporosis

HORIZON : Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis

Zoledronic Acid Recurrent Fracture Trial

Pituitary Disorders 2 Topics

Lesson Content

0% Complete 0/2 Steps

PASIREOTIDE B2305 STUDY GROUP : A 12-month phase 3 study of pasireotide in Cushing’s disease

COPEPTIN – A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus

Lipidology and Obesity 13 Topics

Lesson Content

0% Complete 0/13 Steps

RECORD: Rosiglitazone Evaluated for Cardiovascular Outcomes in oRal agent combination therapy for type 2 Diabetes mellitus

4S : The Scandinavian Simvastatin Survival Study

JUPITER – Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein

IMPROVE-IT : Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

HPS3/TIMI55 : Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

HOPE-3 Trial : Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease

ASCEND : Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus

CAMELLIA-TIMI 61 : Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients

STAMPEDE : Bariatric surgery versus intensive medical therapy in obese patients with diabetes

ORIGIN N-3 Fatty Acid

ODYSSEY OUTCOMES : Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

Hypertension and Adrenal Disorders 2 Topics

Lesson Content

0% Complete 0/2 Steps

SPYRAL HTN-ON MED

Thyroid Diseases 7 Topics

Lesson Content

0% Complete 0/7 Steps

SCH – Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy.

OPTIC – Treatment of Graves’ Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in a Clinical Study

TABLET – Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception. Thyroid AntiBodies and LEvoThyroxine study